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anti-Mouse (Murine) Angiopoietin 2 Antibodies:
anti-Human Angiopoietin 2 Antibodies:
anti-Rat (Rattus) Angiopoietin 2 Antibodies:
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Human Polyclonal Angiopoietin 2 Primary Antibody for FACS, IHC (p) - ABIN654062
Morrissey, Dowell, Koreckij, Nguyen, Lakely, Fanslow, True, Corey, Vessella: Inhibition of angiopoietin-2 in LuCaP 23.1 prostate cancer tumors decreases tumor growth and viability. in The Prostate 2010
Show all 3 Pubmed References
Chicken Monoclonal Angiopoietin 2 Primary Antibody for ICC, IHC (fro) - ABIN259881
Laquer, Dao, Pavlis, Nguyen, Chen, Harris, Rugg, Kelly: Immunohistochemistry of angiogenesis mediators before and after pulsed dye laser treatment of angiomas. in Lasers in surgery and medicine 2012
Show all 2 Pubmed References
Human Polyclonal Angiopoietin 2 Primary Antibody for IF (p), IHC (p) - ABIN671781
Lv, Fan, Su: Is a swine model of arteriovenous malformation suitable for human extracranial arteriovenous malformation? A preliminary study. in Cardiovascular and interventional radiology 2013
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Human Polyclonal Angiopoietin 2 Primary Antibody for IHC, IHC (p) - ABIN4280609
Zhou, Fang, Shang, Zhang, Sang, Xu, Yuan, Chen, Zheng, Zhang, Zhuang: MicroRNAs miR-125b and miR-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulate tumour clusters. in The Journal of pathology 2016
Mouse (Murine) Polyclonal Angiopoietin 2 Primary Antibody for WB - ABIN95113
Câmpean, Karpe, Haas, Atalla, Peters, Rupprecht, Liebner, Acker, Plate, Amann: Angiopoietin 1 and 2 gene and protein expression is differentially regulated in acute anti-Thy1.1 glomerulonephritis. in American journal of physiology. Renal physiology 2008
Human Polyclonal Angiopoietin 2 Primary Antibody for WB - ABIN1043684
Davis, Aldrich, Jones, Acheson, Compton, Jain, Ryan, Bruno, Radziejewski, Maisonpierre, Yancopoulos: Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. in Cell 1997
Shear stress activated Ang-2 via canonical Wnt (show WNT2 Antibodies) signaling in vascular endothelial cells, and Wnt (show WNT2 Antibodies)-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.
These results indicate that the Angpt-Tie2 (show TEK Antibodies) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (show TEK Antibodies) agonists could be a therapeutic option for glaucoma.
ANG2 activation of Tie2 (show TEK Antibodies) supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 (show TIE1 Antibodies) in inflammation leads to ANG2 antagonism of Tie2 (show TEK Antibodies) and initiates a positive feedback loop wherein FOXO1 (show FOXO1 Antibodies)-driven ANG2 expression promotes vascular remodeling and leakage
A balanced expression of the Ang1 (show ANGPT1 Antibodies)/Ang2 system is important for islet physiology. Ang-2 prevents beta-cell mass and islet vascular adaptation in response to HFD feeding with no major influence on glucose homeostasis
These results underscore a pivotal role of Kaposi's sarcoma-associated herpesvirus -induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation.
NDPKB (show NME1 Antibodies) is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.
miR (show MLXIP Antibodies)-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.
Ang-2 blockage was beneficial as it decreased fatty streak formation and plasma triglyceride levels, but had no adverse effect on pre-existing atherosclerosis in hypercholesterolemic mice.
The results establish Ang2-mediated beta1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 (show ANGPT1 Antibodies) and Ang2.
Alprostadil treatment can protect renal function by reducing proteinuria. These effects are mediated, at least in part, through down-regulation of Ang-2 and IL-18 (show IL18 Antibodies) expression
ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development
High ANG2 expression is associated with angiogenesis and metastasis via IGF1 (show IGF1 Antibodies)-IGF1R (show IGF1R Antibodies) signaling in epithelial ovarian cancer.
Our novel noninvasive liver fibrosis model, based on serum angiopoietin-2 levels, outperforms other indices and should help substantially in managing CHC (show CLTC Antibodies) and monitoring long-term follow-up prognosis
Tie1 (show TIE1 Antibodies) directly interacts with Tie2 (show TEK Antibodies) to promote ANG (show ANG Antibodies)-induced vascular responses under noninflammatory conditions, whereas in inflammation, Tie1 (show TIE1 Antibodies) cleavage contributes to loss of ANG2 agonist activity and vascular stability
This systematic review and meta-analysis suggested that serum Ang-2 levels might be a potential predictor for staging, and were associated with prognosis of lung cancer.
Studied angiopoietin-1 (Ang-1 (show ANGPT1 Antibodies)) and angiopoietin-2 (Ang-2) within the intervertebral disc (IVD (show IVD Antibodies)) and elucidated their functions in the regulation of nucleus pulposus (NP) cells. Found the ratio of Ang-2/Ang-1 (show ANGPT1 Antibodies) in tissues from patients increased markedly with increasing age and level of degeneration of the IVD (show IVD Antibodies). Results indicate Ang-2 plays a role in suppressing cell adhesion&viability, and promotes the apoptosis of NP cells.
ANG-1 (show ANGPT1 Antibodies), ANG-2 and TIE-2 (show TEK Antibodies) levels were significantly increased in placenta of non-complicated ART pregnancies compared to placentas from spontaneous conception.
Analyses of human gastric cancer tissues showed a strong correlation between DARPP-32 (show PPP1R1B Antibodies) and ANGPT2. The role of DARPP-32 (show PPP1R1B Antibodies)-STAT3 (show STAT3 Antibodies) axis in regulating ANGPT2 in cancer cells to promote angiogenesis and tumorigenesis.
ANGPT2 expression was upregulated in cerebral cavernous malformation lesions.
In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells. Tie-2 (show TEK Antibodies) expression in tumor cells predicted poorer prognosis.Our data support that dual inhibition of Ang-1 (show ANGPT1 Antibodies) and Ang-2 may be an alternative target for anti-angiogenic adjuvant therapy in advanced or recurrent cervical squamous cell cancer.
expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
forward mandibular positioning enhance the expression of Ang1 (show ANGPT1 Antibodies) and Ang2 in condylar cartilage.
These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha (show HIF1A Antibodies) binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
Activation of the PI3-K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN (show PTEN Antibodies)/PI3-K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway could affect the angiogenic process.
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
, Angiopoietin-2B (Ang-2B)