Angiopoietin-related protein 1 (Angiopoietin-3) is a secreted protein with homology to human angiopoietin-1 and human angiopoietin-2. Angiopoietin-3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells. VEGF slightly increases Angiopoietin-3 mRNA expression in cultured human umbilical vein endothelial cells. Angiopoietin 3 (ANG3), also called ANG4, might represent counterparts in mouse and human. Based on chromosomal analysis, mouse ANG3 is thought to be an ortholog of human ANG4. Human ANG4 acts as an agonist that binds and activates Tie2, whereas mouse ANG3 is likely to be a Tie2 antagonist, exerting agonist or antagonist activities depending on the cell context.
Each vial contains 0.1 mg IgG in 0.1 mL of PBS pH7.4, 1% BSA with 0.09% sodium azide.
Precaution of Use
Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.