You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Rat (Meriones) FLT1 antibody for Western Blotting

Recommended FLT1 Antibody (supplied by: Log in to see )

Antigen
Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) Antibodies
  • AI323757
  • FLT
  • FLT-1
  • Flt-1
  • FLT1
  • flt1b
  • sFlt1
  • VEGFR-1
  • VEGFR1
Reactivity
Human, Mouse (Murine), Rat (Meriones)
245
74
64
12
4
2
2
2
2
2
2
1
1
1
1
1
1
Host
Rabbit
188
86
7
4
1
1
Clonality
Polyclonal
Conjugate
This FLT1 antibody is un-conjugated
15
10
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
171
132
55
48
37
25
21
16
12
11
11
5
2
2
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Catalog No. ABIN2801854
$ 324.50
Plus shipping costs $45.00

Top referenced anti-FLT1 antibody for Western Blotting

Similar anti-FLT1 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Meriones)
Western Blotting (WB) 153 Antibodies 43 Antibodies 1 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Immunoprecipitation (IP) 55 Antibodies 10 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 34 Antibodies 12 Antibodies
Immunohistochemistry (IHC) 50 Antibodies 22 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 13 Antibodies 3 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies 11 Antibodies
Immunofluorescence (IF) 24 Antibodies 7 Antibodies
Immunocytochemistry (ICC) 10 Antibodies

General

Antigen Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) Antibodies
Reactivity Human, Mouse (Murine), Rat (Meriones)
(245), (74), (64), (12), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Host Rabbit
(188), (86), (7), (4), (1), (1)
Clonality
Polyclonal
Conjugate This FLT1 antibody is un-conjugated
(15), (10), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Western Blotting (WB)
(171), (132), (55), (48), (37), (25), (21), (16), (12), (11), (11), (5), (2), (2), (1), (1), (1), (1)
Pubmed 2 references available
Supplier Log in to see

Product Details anti-FLT1 Antibody

Target Details FLT1 Application Details Handling References for anti-FLT1 Antibody (ABIN2801854) Images
Isotype IgG

Target Details FLT1

Product Details anti-FLT1 Antibody Application Details Handling References for anti-FLT1 Antibody (ABIN2801854) Images back to top
Antigen
Alternative Name VEGFR1 (FLT1 Antibody Abstract)
Background Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain, it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.
Synonyms: Vascular endothelial growth factor receptor 1, VEGFR-1, Fms-like tyrosine kinase 1, FLT-1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, FLT, Vascular permeability factor receptor, FLT1, FLT, FRT, VEGFR1
Molecular Weight 150769 Da
Gene ID 2321
UniProt P17948
Pathways RTK Signaling

Application Details

Product Details anti-FLT1 Antibody Target Details FLT1 Handling References for anti-FLT1 Antibody (ABIN2801854) Images back to top
Application Notes WB - 1:500-1:1000
Restrictions For Research Use only

Handling

Product Details anti-FLT1 Antibody Target Details FLT1 Application Details References for anti-FLT1 Antibody (ABIN2801854) Images back to top
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

References for anti-FLT1 Antibody (ABIN2801854)

Product Details anti-FLT1 Antibody Target Details FLT1 Application Details Handling Images back to top
Product cited in:

Herley, Yu, Whitney, Sato: "Characterization of the VEGF binding site on the Flt-1 receptor." in: Biochemical and biophysical research communications, Vol. 262, Issue 3, pp. 731-8, 1999

Kendall, Thomas: "Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 22, pp. 10705-9, 1993

Images

Product Details anti-FLT1 Antibody Target Details FLT1 Application Details Handling References for anti-FLT1 Antibody (ABIN2801854) back to top
Supplier Images
Western Blotting (WB) image for anti-FLT1 antibody (Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor)) (ABIN2801854) anti-Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) antibody