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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||273 Antibodies||81 Antibodies||79 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Neutralization (Neut)||3 Antibodies|
|Intracellular Staining (ICS)||1 Antibodies||1 Antibodies||1 Antibodies|
|Immunoprecipitation (IP)||40 Antibodies||7 Antibodies||5 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||79 Antibodies||36 Antibodies||36 Antibodies|
|Immunohistochemistry (IHC)||108 Antibodies||34 Antibodies||33 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||4 Antibodies|
|Antigen||Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This IGF1R antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Product Details anti-IGF1R AntibodyTarget Details IGF1R Application Details Handling Images
|Specificity||This antibdoy detects endogenous levels of IGF1R protein only when phosphorylated at Tyr980.|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purity||> 95 % by SDS-PAGE|
Target Details IGF1RProduct Details anti-IGF1R Antibody Application Details Handling Images back to top
|Alternative Name||CD221 / IGF1R (IGF1R Antibody Abstract)|
|Background||Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand insulin-like growth factor-I (IGF-I) promotes association of IGFIR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGFIR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into alpha and beta subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.Synonyms: IGF-I receptor, IGF1 Receptor, Insulin-like growth factor 1 receptor|
|Molecular Weight||approx. 95,155 kDa|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-IGF1R Antibody Target Details IGF1R Handling Images back to top
Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IGF1R Antibody Target Details IGF1R Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-IGF1R Antibody Target Details IGF1R Application Details Handling back to top