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|Antigen||Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme (PPP3CC) Antibodies|
|Epitope||AA 480-509, C-Term Alternatives|
|Conjugate||This PPP3CC antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-PPP3CC AntibodyTarget Details PPP3CC Application Details Handling References for anti-PPP3CC Antibody (ABIN360813) Images
|Specificity||This antibody recognizes PPP3CC.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human.|
|Purification||Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS|
|Immunogen||KLH conjugated synthetic peptide between 480~509 amino acids from the C-terminal region of Human PPP3CC.|
Target Details PPP3CCProduct Details anti-PPP3CC Antibody Application Details Handling References for anti-PPP3CC Antibody (ABIN360813) Images back to top
|Alternative Name||PPP3CC / CALNA3 (PPP3CC Antibody Abstract)|
|Background||Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma, have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95 % amino acid identity).Synonyms: CAM-PRP catalytic subunit, CNA3, Calcineurin testis-specific catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, protein phosphatase 2B catalytic subunit gamma|
|Pathways||RTK Signaling, WNT Signaling|
Application DetailsProduct Details anti-PPP3CC Antibody Target Details PPP3CC Handling References for anti-PPP3CC Antibody (ABIN360813) Images back to top
ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PPP3CC Antibody Target Details PPP3CC Application Details References for anti-PPP3CC Antibody (ABIN360813) Images back to top
|Buffer||PBS with 0.09 % (W/V) Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-PPP3CC Antibody (ABIN360813)Product Details anti-PPP3CC Antibody Target Details PPP3CC Application Details Handling Images back to top
Eastwood, Burnet, Harrison: "Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia." in: Biological psychiatry, Vol. 57, Issue 7, pp. 702-10, 2005 (PubMed).
Gerber, Hall, Miyakawa et al.: "Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 15, pp. 8993-8, 2003 (PubMed).
Bennasser, Badou, Tkaczuk et al.: "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha." in: Virology, Vol. 303, Issue 1, pp. 174-80, 2002 (PubMed).
Esau, Boes, Youn et al.: "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells." in: The Journal of experimental medicine, Vol. 194, Issue 10, pp. 1449-59, 2001 (PubMed).
Muramatsu, Kincaid: "Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)." in: Biochemical and biophysical research communications, Vol. 188, Issue 1, pp. 265-71, 1992 (PubMed).
ImagesProduct Details anti-PPP3CC Antibody Target Details PPP3CC Application Details Handling References for anti-PPP3CC Antibody (ABIN360813) back to top