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anti-Rat (Meriones) SHC1 antibody for Western Blotting

Recommended SHC1 Antibody (supplied by: Log in to see )

Antigen
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Antibodies
  • p66
  • p66shc
  • P66shc
  • shc
  • SHC
  • Shc
  • SHC1
  • ShcA
  • SHCA
  • si:dkey-246i14.4
  • wu:fc10h03
Reactivity
Human, Mouse (Murine), Rat (Meriones)
216
170
132
10
6
6
2
2
1
1
Host
Rabbit
202
25
Clonality
Polyclonal
Conjugate
This SHC1 antibody is un-conjugated
7
7
6
5
5
5
5
5
5
5
5
5
1
1
1
Application
Western Blotting (WB)
166
78
60
56
49
33
8
7
6
4
3
1
1
Supplier
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Catalog No. ABIN2801945
$ 324.50
Plus shipping costs $45.00

Top referenced anti-SHC1 antibody for Western Blotting

  • Human Polyclonal SHC1 Primary Antibody for WB - ABIN2801945 (3 Publications): Migliaccio, Mele, Salcini, Pelicci, Lai, Superti-Furga, Pawson, Di Fiore, Lanfrancone, Pelicci: Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. in The EMBO journal 1997 (PubMed)

Similar anti-SHC1 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Meriones)
Western Blotting (WB) 160 Antibodies 113 Antibodies 1 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Immunoprecipitation (IP) 11 Antibodies 7 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 36 Antibodies 26 Antibodies
Immunohistochemistry (IHC) 81 Antibodies 49 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 7 Antibodies 5 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 56 Antibodies 56 Antibodies
Immunofluorescence (IF) 61 Antibodies 34 Antibodies

General

Antigen SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Antibodies
Reactivity Human, Mouse (Murine), Rat (Meriones)
(216), (170), (132), (10), (6), (6), (2), (2), (1), (1)
Host Rabbit
(202), (25)
Clonality
Polyclonal
Conjugate This SHC1 antibody is un-conjugated
(7), (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1)
Application Western Blotting (WB)
(166), (78), (60), (56), (49), (33), (8), (7), (6), (4), (3), (1), (1)
Pubmed 3 references available
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Product Details anti-SHC1 Antibody

Target Details SHC1 Application Details Handling References for anti-SHC1 Antibody (ABIN2801945) Images
Isotype IgG

Target Details SHC1

Product Details anti-SHC1 Antibody Application Details Handling References for anti-SHC1 Antibody (ABIN2801945) Images back to top
Antigen
Alternative Name Shc (SHC1 Antibody Abstract)
Background Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
Synonyms: SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, SH2 domain protein C1, SHC1, SHC, SHCA
Molecular Weight 62822 Da
Gene ID 6464
UniProt P29353
Pathways RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-SHC1 Antibody Target Details SHC1 Handling References for anti-SHC1 Antibody (ABIN2801945) Images back to top
Application Notes WB - 1:1000
Restrictions For Research Use only

Handling

Product Details anti-SHC1 Antibody Target Details SHC1 Application Details References for anti-SHC1 Antibody (ABIN2801945) Images back to top
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

References for anti-SHC1 Antibody (ABIN2801945)

Product Details anti-SHC1 Antibody Target Details SHC1 Application Details Handling Images back to top
Product cited in:

Goshima, Kawamura, Fukumoto, Miura, Honma, Satoh, Wakamatsu, Yamamoto, Kimura, Nishikawa, Andoh, Iida, Ishikawa, Ito, Kagawa, Kaminaga, Kanehori, Kawakami, Kenmochi, Kimura, Kobayashi, Kuroita et al.: "Human protein factory for converting the transcriptome into an in vitro-expressed proteome,. ..." in: Nature methods, Vol. 5, Issue 12, pp. 1011-7, 2008

Migliaccio, Mele, Salcini, Pelicci, Lai, Superti-Furga, Pawson, Di Fiore, Lanfrancone, Pelicci: "Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway." in: The EMBO journal, Vol. 16, Issue 4, pp. 706-16, 1997

Background publications

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003

Images

Product Details anti-SHC1 Antibody Target Details SHC1 Application Details Handling References for anti-SHC1 Antibody (ABIN2801945) back to top
Supplier Images
Western Blotting (WB) image for anti-SHC1 antibody (SHC (Src Homology 2 Domain Containing) Transforming Protein 1) (ABIN2801945) anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) antibody