anti-Rat (Rattus) TRKA antibody for Enzyme Immunoassay

Recommended TRKA Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
  • trk
  • trka
  • TRKA
  • MTC
  • TRK
  • TRK1
  • Trk-A
  • p140-TrkA
  • C80751
  • Tkr
  • TrkA
  • Trk
  • CTRKA
  • trkA
  • CAPM1
  • CFTD
  • NEM1
  • OK/SW-cl.5
  • TM-5
  • TM3
  • TM30
  • TM30nm
  • TM5
  • TPMsk3
  • hscp30
  • neurotrophic tyrosine kinase, receptor, type 1
  • tropomyosin 3
  • ntrk1
  • NTRK1
  • LOC100354292
  • Ntrk1
  • TPM3
Reactivity
Human, Mouse (Murine), Rat (Rattus)
420
246
198
2
2
Host
Rabbit
381
64
4
4
3
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
17
15
15
11
9
9
8
8
8
8
8
7
7
7
7
7
6
2
2
2
2
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
262
148
92
88
58
57
56
43
19
10
5
5
3
3
2
1
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Catalog No. ABIN272088
$ 390.50
Plus shipping costs $45.00

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(420), (246), (198), (2), (2)
Host Rabbit
(381), (64), (4), (4), (3)
Clonality
Polyclonal
Conjugate This TRKA antibody is un-conjugated
(17), (15), (15), (11), (9), (9), (8), (8), (8), (8), (8), (7), (7), (7), (7), (7), (6), (2), (2), (2), (2), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(262), (148), (92), (88), (58), (57), (56), (43), (19), (10), (5), (5), (3), (3), (2), (1)
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Product Details anti-TRKA Antibody

Target Details TRKA Application Details Handling Images
Specificity This antibody detects endogenous levels of Trk A protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Purity > 95 % pure by SDS-PAGE

Target Details TRKA

Product Details anti-TRKA Antibody Application Details Handling Images back to top
Antigen
Alternative Name TrkA (NTRK1 Antibody Abstract)
Background TrkA, apparent molecular weight 140 kDa, is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.Synonyms: High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, Trk-A, p140-TrkA
Molecular Weight approx. 87 kDa
Gene ID 4914
NCBI Accession NP_001007793
UniProt P04629
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process

Application Details

Product Details anti-TRKA Antibody Target Details TRKA Handling Images back to top
Application Notes ELISA: 1: 1000approx. 1: 5000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-TRKA Antibody Target Details TRKA Application Details Images back to top
Concentration 1,0 mg/mL
Buffer PBS, pH ~7.2, 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.

Images

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling back to top
Supplier Images
 image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody (ABIN272088) anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody