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anti-Human WASF1 Antibodies:
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Mammalian Monoclonal WASF1 Primary Antibody for ISt, IHC - ABIN1305050
Chazeau, Mehidi, Nair, Gautier, Leduc, Chamma, Kage, Kechkar, Thoumine, Rottner, Choquet, Gautreau, Sibarita, Giannone: Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion. in The EMBO journal 2014
Show all 6 Pubmed References
Cow (Bovine) Polyclonal WASF1 Primary Antibody for ELISA, WB - ABIN4365924
Beli, Mascheroni, Xu, Innocenti: WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2. in Nature cell biology 2008
Lpd (show ACSBG1 Antibodies) regulates mesenchymal neu (show AKT1 Antibodies)ral crest cell migration cell autonomously in Xeno (show ACSBG1 Antibodies)pus laevis via the Scar/WAVE complex.
this sudy identifies Wave1 as a maternal reprogramming factor that also has a necessary role in gene activation in development.
The rapid growth of roots in the light requires a functional ARP2/3-SCAR complex. Light is essential for stabilizing the SCAR complex in the plasma membrane, which is necessary for maintaining longitudinally organized F-actin to sustain rapid root growth.
WASP and SCAR drive pseudopod formation and are conserved in actin-filled pseudopod-based motility.
Results suggested that WAVE1 is a critical pro-autophagic protein capable of enhancing cell survival and regulating chemoresistance in leukemia cells potentially through the Beclin1 (show BECN1 Antibodies)/Bcl-2 (show BCL2 Antibodies) and Beclin1 (show BECN1 Antibodies)/PI3K (show PIK3CA Antibodies)- complex-dependent pathways.
Results implicate a contributory role of WAVE1 and -3 to the metastatic phenotype of PC-3 (show PCSK1 Antibodies) cells through their interaction with the ARP2 (show ACTR2 Antibodies)/3 complex.
we propose that WASF1 status defines a subtype of androgen deprivation therapy -resistant prostate cancer patients
a role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration
A decrease in amounts of WASF1 mRNA was also observed in human Alzheimer's disease brains, suggesting clinical relevance of the negative feedback circuit involved in homeostatic regulation of Abeta (show APP Antibodies) production
D620N mutation in VPS35 (show vps35 Antibodies) restricts WASH complex recruitment to endosomes, and reveals a novel role for the WASH complex in autophagosome formation.
WAVE1 has unique activities independent of Arp2 (show ACTR2 Antibodies)/3 complex that can govern both the growth rates and architectures of actin filament networks. Elongation inhibitory effects of WAVE1 were mapped to its WH2 ("V") domain.
The WAVE complex is the main activator of the Arp2/3 complex for actin filament nucleation and assembly in the lamellipodia of moving cells.
WAVE1 might promote the proliferative and invasive malignant behaviors through the activation of the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and p38MAPK (show MAPK14 Antibodies) signaling pathways in epithelial ovarian cancer.
We identified a phosphorylation-dependent mechanism that regulates selective recruitment of these effectors to Lamellipodin (show RAPH1 Antibodies): Abl (show ABL1 Antibodies)-mediated Lamellipodin (show RAPH1 Antibodies) phosphorylation promotes its association with both Scar/WAVE and Ena/VASP (show VASP Antibodies), whereas Src (show SRC Antibodies)-dependent phosphorylation enhances binding to Scar/WAVE but not to Ena/VASP (show VASP Antibodies)
WAVE1 phosphorylation in podocytes. Synaptopodin (show SYNPO Antibodies) is a well-characterized target of CsA (show HSPA9 Antibodies). WAVE1 overexpression and synaptopodin (show SYNPO Antibodies) knockdown experiments directly demonstrated that WAVE1 expression is not dependent on synaptopodin (show SYNPO Antibodies) expression, and vice versa
Signaling through WAVE-1 plays a critical role in establishing normal synaptic architecture in the rodent hippocampus.
Lpd (show ACSBG1 Antibodies) directly binds active Rac (show AKT1 Antibodies), which regulates a direct interaction between Lpd (show ACSBG1 Antibodies) and the Scar/WAVE complex
An unanticipated role for WAVE1 as a critical modulator of the innate immune response to severe bacterial infections.
Dock3 (show DOCK3 Antibodies) induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex
In cell migration WAVE1 is essential in MMP-dependent migration in extracellular matrix and WAVE2 (show WASF2 Antibodies) is for leading edge extension for directed migration in general.
Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo.
data suggest that phosphorylation/dephosphorylation of WAVE1 in neurons has an important role in the formation of the filamentous actin cytoskeleton, and thus in the regulation of dendritic spine morphology
NESH (Abi-3 (show ABI3 Antibodies)), like Abi-1 (show ABI1 Antibodies) and Abi-2 (show ABI2 Antibodies), is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl (show ABL1 Antibodies).
Data show that WAVE1 sequestration to the nucleus is required during fertilization, and is an actin-independent event that relies on dynamic microtubules but not nuclear pores.
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
WASP family protein member 1
, homology of dictyostelium scar 1
, protein WAVE-1
, verprolin homology domain-containing protein 1
, wiskott-Aldrich syndrome protein family member 1
, WASP family 1