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SH2 Domain Protein 2A Proteins (SH2D2A)
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Synonyms:
F2771, Lad, Ribp, SCAP, Tsad, VRAP
list all proteins Gene Name GeneID UniProt
SH2D2A 9047 Q9NP31
Rat SH2D2A SH2D2A 310688  
SH2D2A 27371 Q9QXK9

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SH2 Domain Protein 2A Proteins (SH2D2A) by Origin

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More Proteins for SH2 Domain Protein 2A Interaction Partners

Human SH2 Domain Protein 2A (SH2D2A) interaction partners

  1. Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen (show CD6 Proteins) and linker for activation of T cells (show LAT Proteins) protein (LAT (show ORC3 Proteins)) phosphotyrosine (pTyr) peptides.

  2. TSAD binds to and co-localizes with Nck (show NCK1 Proteins). Expression of TSAD increases both Nck (show NCK1 Proteins)-Lck (show LCK Proteins) and Nck (show NCK1 Proteins)-SLP-76 (show LCP2 Proteins) interaction in T cells.

  3. The kinase Itk (show ITK Proteins) and the adaptor TSAd change the specificity of the kinase Lck (show LCK Proteins) in T cells by promoting the phosphorylation of Tyr192.

  4. Data indicate the expression pattern of T cell-specific adapter protein (TSAd) in various healthy lymphoid and non-lymphoid tissues.

  5. in chronic inflammatory demyelinating polyneuropathy we found an association with a homozygous genotype for a low repeat number of tandem GA in the SH2D2A gene

  6. TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements

  7. TSAd associates with laminin binding protein (show RPSA Proteins) and mediates T lymphocyte migration during T cell activation

  8. TSAd appears to contribute to interleukin-2 (show IL2 Proteins) synthesis at multiple different levels

  9. upon chemokine (show CCL1 Proteins) stimulation, Lad (show DLD Proteins) acts as an adaptor protein that links the G protein beta subunit (show GNB3 Proteins) to the tyrosine kinases Lck (show LCK Proteins) and Zap-70 (show ZAP70 Proteins), thereby mediating T-cell migration

  10. SH2D2A expression is regulated both at the transcriptional and translational level.

Mouse (Murine) SH2 Domain Protein 2A (SH2D2A) interaction partners

  1. Sh2d2a protein deficient mice display reduced clearance of Dm157 MCMV infection in the spleen.

  2. The kinase Itk (show ITK Proteins) and the adaptor TSAd change the specificity of the kinase Lck (show LCK Proteins) in T cells by promoting the phosphorylation of Tyr192.

  3. Results suggest a modulatory role for T cell specific adapter protein SH2D2A in T cell mediated immune surveillance of cancer.

  4. Data show that tyrosine phosphorylation of VEGF receptor 2 (VEGFR2) facilitates binding of VEGFR2 (show KDR Proteins) to the Rous sarcoma (Src (show SRC Proteins)) homology 2-domain of T cell-specific adaptor (TSAd), which in turn regulates VEGF (show VEGFA Proteins)-induced activation of the c-Src tyrosine kinase (show CSK Proteins).

  5. results show that TSAd, particularly the SH2 domain of TSAd, is essential for the effector functions of T cells.

  6. TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements

  7. role of TSAd as a critical regulator of T cell death whose absence promotes systemic autoimmunity

  8. TSAd appears to contribute to interleukin-2 (show IL2 Proteins) synthesis at multiple different levels

  9. The major role of T cell-specific adapter protein in peripheral T cell cytoplasm is for activation of LCK (show LCK Proteins) protein tyrosine kinase (show YES1 Proteins) at the outset of T cell receptor signal transduction

  10. Although Rlk/Itk-binding protein (RIBP) is coexpressed with related adaptor lymphocytes of unknown function X (ALX) protein on both T- and B-lymphocytes during cell development, no redundancy or synergy is found.

SH2 Domain Protein 2A (SH2D2A) Protein Profile

Protein Summary

This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SH2 Domain Protein 2A (SH2D2A)

  • SH2 domain containing 2A (SH2D2A)
  • SH2 domain containing 2A (Sh2d2a)
  • SH2 domain protein 2A (Sh2d2a)
  • F2771 protein
  • Lad protein
  • Ribp protein
  • SCAP protein
  • Tsad protein
  • VRAP protein

Protein level used designations for SH2 Domain Protein 2A Proteins (SH2D2A)

SH2 domain protein 2A , SH2 domain-containing protein 2A , T cell specific adapter protein TSAd , T lymphocyte specific adaptor protein , VEGF receptor-associated protein , Lck-associated adapter protein , Rlk/Itk-binding protein , T cell-specific adapter protein , p56Lck-associated adapter protein

GENE ID SPECIES
9047 Homo sapiens
100687395 Canis lupus familiaris
530059 Bos taurus
310688 Rattus norvegicus
27371 Mus musculus
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