Browse our SORL1 Proteins (SORL1)

Full name:
Sortilin-Related Receptor, L(DLR Class) A Repeats Containing Proteins (SORL1)
On www.antibodies-online.com are 2 Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) Proteins from 2 different suppliers available. Additionally we are shipping SORL1 Antibodies (98) and SORL1 Kits (9) and many more products for this protein. A total of 113 SORL1 products are currently listed.
Synonyms:
2900010L19Rik, AI596264, AW261561, C11orf32, gp250, Lr11, LRP9, mSorLA, RGD619914, SORL1, SorLA, SorLA-1
list all proteins Gene Name GeneID UniProt
SORL1 6653 Q92673
Mouse SORL1 SORL1 20660 O88307
Rat SORL1 SORL1 300652  

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SORL1 Proteins (SORL1) by Origin

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More Proteins for SORL1 Interaction Partners

Human Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) interaction partners

  1. SorLA ectodomain, released from the cell membrane upon enzymatic cleavage of full-length SorLA, may act as an IL-6 (show IL6 Proteins) carrier protein that stabilizes IL-6 (show IL6 Proteins) and its capacity for trans signaling.

  2. observed a 1.5-fold enrichment of rare non-synonymous variants of sortilin-related receptor 1 in Alzheimer's disease patients

  3. This review article discusses the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases. [review]

  4. The presence of rare coding variants in SORL1 in three different European American cohorts: early-onset, late-onset AD (LOAD) and familial LOAD, was examined.

  5. sLR11 levels in bile may be indicative of cancer cell conditions and may serve as potential novel biomarker in patients with BTC (show BTC Proteins) and PC

  6. SORL1 protein is involved with late onset Alzheimer's disease. [review]

  7. The DNA methylation (show HELLS Proteins) of the SORL1 5'-flanking region may significantly influence the manifestation of mild cognitive impairment in T2 Diabetes mellitus, and might be associated with its neurocognitive presentation.

  8. Findings provide evidence that sortilin (show SORT1 Proteins) receptor 1 rs3824968 modulates regional gray matter volume and is associated with brain trajectory during the adult lifespan.

  9. Serum LR11 reflects the development of vascular lesions in patients with serious coronary artery lesions.

  10. Elevated sLR11 levels may increase the cardiovascular disease risk especially in subjects with delayed clearance of triglyceride-rich remnants, such as in familial hypercholesterolemia patients.

Mouse (Murine) Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) interaction partners

  1. SorLA ectodomain, released from the cell membrane upon enzymatic cleavage of full-length SorLA, may act as an IL-6 (show IL6 Proteins) carrier protein that stabilizes IL-6 (show IL6 Proteins) and its capacity for trans signaling.

  2. We identify binding and trafficking interactions between two of these factors, SORLA and SNX27 (show SNX27 Proteins), and demonstrate that SNX27 (show SNX27 Proteins) can direct trafficking of SORLA and the Abeta (show APP Proteins) precursor APP (show APP Proteins) to the cell surface to limit the production of Abeta (show APP Proteins). Diversion APP (show APP Proteins) to the cell surface through modulation of this molecular complex may represent a complimentary strategy for future development in AD treatment.

  3. LR11 regulated vascular smooth muscle cell proliferation during the progression of hypoxia-induced medial thickening in mice.

  4. Therefore, SORL1 activation by 6-shogaol provides neuronal cell survival through the inhibition of Abeta (show APP Proteins) production. These results indicate that 6-shogaol should be regarded as an SORL1 activator and a potential preventive agent for the treatment of AD.

  5. Data strongly suggest an involvement of LR11 in mediating the harmful effects of a high-fat diet on CVD progression.

  6. Mice lacking LR11 are protected from diet-induced obesity associated with an increased browning of white adipose tissue and hypermetabolism.

  7. using massively parallel reporter assays, we dissect the enhancer activity of three liver eExons (SORL1 exon 17, TRAF3IP2 (show TRAF3IP2 Proteins) exon 2, PPARG (show PPARG Proteins) exon 6) at single nucleotide resolution in the mouse liver

  8. Data indicate that activation of alpha(2A) adrenergic receptor (alpha(2A)AR (show ADRA2A Proteins)) signaling disrupts transgenic amyloid precursor protein (APP (show APP Proteins)) interaction with sorting-related receptor with A repeat (SorLA) in cells and brain.

  9. SORLA-mediated trafficking of TrkB (show NTRK2 Proteins) enhances the response of neurons to BDNF (show BDNF Proteins).

  10. SorLA acts as sorting receptor for the GDNF (show GDNF Proteins)/GFRalpha1 (show GFRA1 Proteins) complex, directing it from the cell surface to endosomes.

SORL1 Protein Profile

Protein Summary

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.

Alternative names and synonyms associated with SORL1

  • sortilin-related receptor, L(DLR class) A repeats containing (sorl1)
  • sortilin-related receptor, L(DLR class) A repeats-containing (SORL1)
  • sortilin-related receptor, L(DLR class) A repeats-containing (LOC100226349)
  • sortilin-related receptor, L(DLR class) A repeats-containing (sorl1)
  • sortilin-related receptor, L(DLR class) A repeats containing (SORL1)
  • sortilin-related receptor, LDLR class A repeats-containing (Sorl1)
  • 2900010L19Rik protein
  • AI596264 protein
  • AW261561 protein
  • C11orf32 protein
  • gp250 protein
  • Lr11 protein
  • LRP9 protein
  • mSorLA protein
  • RGD619914 protein
  • SORL1 protein
  • SorLA protein
  • SorLA-1 protein

Protein level used designations for SORL1

sortilin-related receptor, L(DLR class) A repeats containing , sortilin-related receptor, L(DLR class) A repeats-containing , sortilin-related receptor-like , LDLR relative with 11 ligand-binding repeats , low-density lipoprotein receptor relative with 11 ligand-binding repeats , mosaic protein LR11 , sortilin-related receptor , sorting protein-related receptor containing LDLR class A repeats , LR11 , sorLA , sorLA-1

GENE ID SPECIES
100566946 Anolis carolinensis
582560 Strongylocentrotus purpuratus
713011 Macaca mulatta
100024063 Monodelphis domestica
100071572 Equus caballus
100073504 Ornithorhynchus anatinus
100226349 Taeniopygia guttata
100490681 Xenopus (Silurana) tropicalis
100524036 Sus scrofa
6653 Homo sapiens
479408 Canis lupus familiaris
533166 Bos taurus
395998 Gallus gallus
100009378 Oryctolagus cuniculus
20660 Mus musculus
300652 Rattus norvegicus
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