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Browse our Nucleoporin 98kDa Proteins (NUP98)

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Nucleoporin 98kDa Proteins (NUP98)
On are 10 Nucleoporin 98kDa (NUP98) Proteins from 4 different suppliers available. Additionally we are shipping Nucleoporin 98kDa Antibodies (64) and Nucleoporin 98kDa Kits (18) and many more products for this protein. A total of 99 Nucleoporin 98kDa products are currently listed.
4732457F17, ADIR2, AI849286, CG10198, CG10201, Dmel\\CG10198, GB12688, im:7151238, l(3)95BCd, Nup-98, Nup 96, NUP96, NUP98, Nup 98, nup98-96, Nup98-Nup96, Nup98/96, nup145, NUP196, zgc:63593, zgc:113968
list all proteins Gene Name GeneID UniProt
NUP98 269966  
Rat NUP98 NUP98 81738 P49793
NUP98 4928 P52948

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Nucleoporin 98kDa Proteins (NUP98) by Origin

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More Proteins for Nucleoporin 98kDa Interaction Partners

Fruit Fly (Drosophila melanogaster) Nucleoporin 98kDa (NUP98) interaction partners

  1. Nup98 associates and colocalizes with the MBD (show DPEP1 Proteins)-R2/NSL and Trx (show GSR Proteins) complexes. Nup98 regulates transcription of Trx (show GSR Proteins) targets, the Hox (show MSH2 Proteins) genes.

  2. Nup98, a virus-induced gene, was antiviral against a panel of viruses.

  3. Study analyzed genomic interactions of full-length nucleoporins Nup98, Nup50 (show NUP50 Proteins), and Nup62 and found that they predominantly interacted with active genes inside the nucleoplasm, particularly those involved in developmental regulation and the cell cycle.

  4. Nup88 (show NUP88 Proteins) localizes to silent loci, Sec13 (show SEC13 Proteins), Nup98, and a subset of FG-repeat nucleoporins bind to developmentally regulated genes undergoing transcription induction.

Mouse (Murine) Nucleoporin 98kDa (NUP98) interaction partners

  1. The age-associated accumulation of somatic mutations that occurs in the Nup98-HOXD13 (show HOXD13 Proteins) (NHD13) mouse model of leukemia progression was significantly elevated by co-expression of a PKR (show EIF2AK2 Proteins) transgene.

  2. Nup50 (show NUP50 Proteins) dynamics are independent of importin alpha (show KPNA4 Proteins), Nup153 (show NUP153 Proteins), and Nup98, even though the latter two proteins also exhibit transcription-dependent mobility.

  3. Data indicate that loss of cyclin-dependent kinase inhibitor p15 (p15Ink4b (show CDKN2B Proteins)) collaborates with oncogene (show RAB1A Proteins) fusion protein Nup98-HoxD13 (show HOXD13 Proteins) transgene in the development of predominantly myeloid neoplasms.

  4. Homeobox (show PRRX1 Proteins) partners create more potent NUP98 fusion oncogenes than do non-homeobox (show PRRX1 Proteins) partners.

  5. findings show that expression of NUP98-HOXD13 (show HOXD13 Proteins) impairs class switch recombination and reduces the antibody-mediated immune response, in addition to its role in leukemia

  6. Mice expressing both the FLT3 (show FLT3 Proteins)/ITD and Nup98-HoxD13 (show HOXD13 Proteins) (NHD13) fusion gene developed acute myeloid leukemia (show BCL11A Proteins) with 100% penetrance

  7. Data show that NUP98-HOXA10HD, a novel, canonical NUP98-Hox (show MSH2 Proteins) fusion, significantly enhances the self-renewal capacity of hematopoietic stem cells.

  8. These results clearly demonstrate that Nup98 functions as a novel shuttling cofactor for Crm1 (show XPO1 Proteins)-mediated nuclear export in conjunction with RanBP3 (show RANBP3 Proteins).

  9. A mouse model of CML blast crisis induced by cooperation between BCR/ABL (show ABL1 Proteins) and NUP98/HOXA9 (show HOXA9 Proteins)

  10. results suggest that Rae1 (show RAE1 Proteins) and Nup98 are temporal regulators of APC (show APC Proteins)(Cdh1 (show CDH1 Proteins)) that maintain euploidy by preventing unscheduled degradation of securin (show PTTG1 Proteins)

Zebrafish Nucleoporin 98kDa (NUP98) interaction partners

  1. data show that a novel nup98 was identified and it serves a role in nucleocytoplasmic trafficking similar to human NUP98.

Human Nucleoporin 98kDa (NUP98) interaction partners

  1. The results indicate that highly selective targeting of Nup98-fusion proteins to Hox (show MSH2 Proteins) cluster regions via prebound Crm1 (show XPO1 Proteins) induces the formation of higher order chromatin structures that causes aberrant Hox (show MSH2 Proteins) gene regulation.

  2. Despite the difference in localization, all tested Nup98 chimera provoked morphological alterations in the nuclear envelope (NE), in particular affecting the nuclear lamina and the lamina-associated polypeptide 2alpha.

  3. NUP98-HOXA9 (show HOXA9 Proteins) expression induces myeloid disease.

  4. Overall, these results demonstrate a novel role for FOXK1 (show FOXK2 Proteins) in regulating the expression of antiviral genes via Nup98, from insects to humans.

  5. deregulation of the retinoid/rexinoid signaling pathway has a major role and may represent a potential therapeutic target for NUP98-RARG (show RARG Proteins)-mediated transformation

  6. Acute myeloid leukemia (show BCL11A Proteins) can be reproduced in mice by transducing mouse mesenchymal stem cells with the human NUP98-NSD1 fusion and the FLT3 (show FLT3 Proteins)-ITD mutated constracts.

  7. These data reveal an emergent Kap (show CDKN3 Proteins)-centric barrier mechanism that may underlie mechanistic and kinetic control in the nuclear pore complex.

  8. Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin (show AGFG2 Proteins) pair (Rae1 (show RAE1 Proteins) * Nup98).

  9. NUP98 oncoproteins predispose myeloid cells to oncogenic transformation or malignant progression by promoting whole chromosome instability.

  10. NUP98/JARID1A is a novel recurrent genetic abnormality in pediatric AMKL

Xenopus laevis Nucleoporin 98kDa (NUP98) interaction partners

  1. These data support a model in which Nup98 interacts with microtubules and antagonizes MCAK (show KIF2C Proteins) activity, thus promoting bipolar spindle assembly.

Nucleoporin 98kDa (NUP98) Protein Profile

Protein Summary

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described.

Alternative names and synonyms associated with Nucleoporin 98kDa (NUP98)

  • Nucleoporin 98-96 (Nup98-96)
  • nucleoporin 98kDa (Nup98)
  • nucleoporin 98kDa (NUP98)
  • nucleoporin 98 (Nup98)
  • nucleoporin 98 (nup98)
  • Nup98 protein (nup98)
  • 4732457F17 protein
  • ADIR2 protein
  • AI849286 protein
  • CG10198 protein
  • CG10201 protein
  • Dmel\\CG10198 protein
  • GB12688 protein
  • im:7151238 protein
  • l(3)95BCd protein
  • Nup-98 protein
  • Nup 96 protein
  • NUP96 protein
  • NUP98 protein
  • Nup 98 protein
  • nup98-96 protein
  • Nup98-Nup96 protein
  • Nup98/96 protein
  • nup145 protein
  • NUP196 protein
  • zgc:63593 protein
  • zgc:113968 protein

Protein level used designations for Nucleoporin 98kDa Proteins (NUP98)

CG10198-PA , CG10198-PC , CG10198-PD , Nup98 , Nup98-96-PA , Nup98-96-PC , Nup98-96-PD , nucleoporin 98 , nucleoporin 98-96 , nucleoporin98-96 , nucleoporin 98kD , nucleoporin 98kDa , nuclear pore complex protein Nup98-Nup96-like , nuclear pore complex protein Nup98-Nup96 , 98 kDa nucleoporin , nuclear pore complex protein Nup98 , nucleoporin Nup98 , GLFG-repeat containing nucleoporin , Nup98-Nup96

42816 Drosophila melanogaster
408335 Apis mellifera
450971 Pan troglodytes
587580 Strongylocentrotus purpuratus
100016427 Monodelphis domestica
100052986 Equus caballus
100090367 Ornithorhynchus anatinus
100414799 Callithrix jacchus
100475098 Ailuropoda melanoleuca
100522560 Sus scrofa
269966 Mus musculus
81738 Rattus norvegicus
777756 Danio rerio
430616 Gallus gallus
4928 Homo sapiens
476822 Canis lupus familiaris
540004 Bos taurus
100343626 Oryctolagus cuniculus
446233 Xenopus laevis
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