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We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 (show SLC12A2 ELISA Kits) rs17764730, PSMB5 (show PSMB5 ELISA Kits) rs941718), and hematocrit (PROX1 rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant
PROX1 serves an oncogenic role in glioblastoma multiforme and promotes cell proliferation and invasiveness potentially via activation of the NFkappa B signaling pathway.
High PROX1 expression is associated with gastric cancer.
High PROX1 expression is associated with Esophageal Squamous Cell Carcinoma.
Reduced expression of Prox1 is beneficial for the expansion and maturation of beta-cells.
PROX1 is an important regulator of endocrine secretory granule formation in medullary thyroid cancer cells.
Findings demonstrate that NOTCH (show NOTCH1 ELISA Kits)-induced PROX1 inactivation significantly promotes the malignant behavior of thyroid carcinoma.
These results suggest that the hepatic functions of the human iPS (show SLC27A4 ELISA Kits)-HLCs (show HLCS ELISA Kits) could be enhanced by ATF5 (show ATF5 ELISA Kits), c/EBPalpha (show CEBPA ELISA Kits), and PROX1 transduction.
In primary lymphatic endothelial cells (HDLEC), miR (show MLXIP ELISA Kits)-466 mimic transfection suppressed Prox1 mRNA and protein expression. HDLEC transfected with the miR (show MLXIP ELISA Kits)-466 mimic suppressed tube formation as compared to the scrambled control.
Increase in PROX1 expression renders HCC (show FAM126A ELISA Kits) cells more resistant to sorafenib treatment.
Data indicate that prospero-related homeobox 1 (Prox1) has a role in regulating energy homeostasis in hepatocytes.
These results are the first demonstration that Prox1 activity protects pancreatic cells from acute tissue damage and early neoplastic transformation. Additional data in our study indicate that this novel role of Prox1 involves suppression of pathways associated with inflammatory responses and cell invasiveness.
the data show that Prox1 regulates proliferation and differentiation of the oligodendrocyte cell lineage, and is a relevant component of the endogenous regenerative response to Central nervous system injury.
Prox1 upregulation reduces proliferation, impairs maturation, and enables apoptosis in postnatal beta-cells. Prox1 overexpression causes MafA (show MAFA ELISA Kits) deficiency in beta-cells.
The PROX1-mediated repression is weakened or lost, thereby facilitating the induction of Reverse cholesterol transport genes and diminishing the progression of atherosclerosis
suggest that Prox1 appears to be a critical stage specific regulator of specifying ascending thin limb cell fate and that its expression is regulated by osmolality
we demonstrate that Prox1 and Asap1 (show ASAP1 ELISA Kits) behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.
Prox1 is made in postmitotic CGE-derived cortical interneuron precursors. It is differentially required during embryonic and postnatal stages for migration, differentiation, circuit integration, and maintenance programs in subtypes of these interneurons.
Sox2 (show SOX2 ELISA Kits) was not restricted to developing taste bud cells expressing Prox1 during circumvallate development.
Expression of fluorescent Prox-1 allows functional characterization of Schlemm's canal.
using a transgenic reporter line, we show that prox1a is initially expressed in different endothelial compartments, becoming restricted to lymphatic endothelial cells only at later stages
Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.
Prox1 functions as a tissue-specific coregulator of Ff1b
Our findings indicate that prox1 activity is crucial for the proper development of the otp1 (show OTOP1 ELISA Kits)-positive hypothalamic neuronal precursors to their terminal CA phenotype
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants.
prospero homeobox 1
, prospero homeobox protein 1-like
, Prox 1
, prospero-related homeobox 1
, homeobox prospero-like protein PROX1
, prospero homeobox protein 1
, prospero-related homeobox gene 1