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anti-Human NMDAR2A Antibodies:
anti-Rat (Rattus) NMDAR2A Antibodies:
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Mammalian Monoclonal NMDAR2A Primary Antibody for ISt, IHC - ABIN1304680
DOrsi, Kilbride, Chen, Perez Alvarez, Bonner, Pfeiffer, Plesnila, Engel, Henshall, Düssmann, Prehn: Bax regulates neuronal Ca2+ homeostasis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Show all 5 Pubmed References
Mouse (Murine) Monoclonal NMDAR2A Primary Antibody for IF, WB - ABIN968802
Ishii, Moriyoshi, Sugihara, Sakurada, Kadotani, Yokoi, Akazawa, Shigemoto, Mizuno, Masu: Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. in The Journal of biological chemistry 1993
Show all 2 Pubmed References
Human Polyclonal NMDAR2A Primary Antibody for IF (p), IHC (p) - ABIN747353
Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. in Neurobiology of disease 2014
Show all 2 Pubmed References
Rat (Rattus) NMDAR2A Primary Antibody for ELISA, WB - ABIN1742591
Wang, Liu, Fu, Wang, Lu: Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. in Nature neuroscience 2003
2-methoxyestradiol impacts on glycine/serine-mediated metabolic reprogramming in osteosarcoma cells by its interaction with GRIN1 (show GRIN1 Antibodies)/GluN2A receptors.
a de novo missense mutation in the GRIN2A gene in a patient with childhood focal epilepsy and acquired epileptic aphasia. The mutant decreases NMDAR (show GRIN1 Antibodies) activation suggesting NMDAR (show GRIN1 Antibodies) hypofunction may contribute to the epilepsy pathogenesis.
genetic association studies in population in China: Data suggest that one SNP in GRIN2A (rs2650429; but not rs6497540 or rs9302415) is associated with lead-induced neurotoxicity; in this case-control study, cases were lead-exposed workers from battery plants. Lead-exposed individuals have lower serum GRIN2A levels compared with controls; lead decreases GRIN2A expression levels in HEK293 cell.
Two adjacent phenylalanines in the NMDA receptor GluN2A subunit M3 domain interactively regulate alcohol sensitivity and ion channel gating.
The GRIN2A genotype was not associated with the rate of clinical progression of PD in the placebo group.
most rare variants in GluN2A were associated with epilepsy, whereas GluN2B (show GRIN2B Antibodies) variants were associated with intellectual disability with or without seizures
the gain-of-function M817V mutation causes overactivation of NMDAR (show GRIN1 Antibodies) and drives neuronal hyperexcitability.
To determine genetic variability within the N-methyl-D-aspartate receptor 2A sub-unit (GRIN2A) gene promoter and its association with concussion recovery time.
Knockdown of PKD1 (show PKD1 Antibodies) did not affect NMDAR (show GRIN1 Antibodies) internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR (show GRIN1 Antibodies)-mediated synaptic functions.
Findings suggest that mutations in GRIN2A preferentially are involved in genetic variance of pediatric idiopathic generalized epilepsy and do not contribute significantly to either adult focal epilepsies as temporal lobe epilepsy or generalized epilepsies
Drebrin A (show DBN1 Antibodies) can be found co-clustering with NR2B (show GRIN2B Antibodies)-containing NMDARs at the plasma membrane, while NR2A-containing NMDARs co-traffic into the spine cytoplasm but do not co-cluster at the plasma membrane.
This study demonstrated that Increasing the GluN2A/GluN2B (show GRIN2B Antibodies) Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace.
Grin2aPKC mice exhibit reduced anxiety in the open field test, light dark emergence test, and elevated plus maze. Overall, these results suggest that at least one of those PKC (show PKC Antibodies)-mediated phosphorylation sites regulates NMDAR (show GRIN1 Antibodies)-mediated signaling that modulates anxiety.
These data suggest that chronic early postnatal SSS influences spatial learning and memory ability, levels of hippocampal NR2B (show GRIN2B Antibodies), and NR2A/NR2B (show GRIN2B Antibodies) ratios in adult males.
Rph3A (show RPH3A Antibodies) interacts with GluN2A and PSD-95 (show DLG4 Antibodies) forming a complex that regulates NMDARs stabilization at postsynaptic membranes.
Egr-1 (show EGR1 Antibodies) is involved in NMDAR (show GRIN1 Antibodies)-mediated PSD-95 (show DLG4 Antibodies) down-regulation and AMPAR endocytosis, a process important in the expression of long term depression
Study demonstrated that GluN2A carboxy-terminal domain is responsible for the impaired long-term olfactory and social memory observed in the GluN2A overexpression mice
Results establish the GluN2A subunit as a significant contributor to both bidirectional synaptic plasticity and spatial pattern separation in the dentate gyrus
Best1 (show BEST1 Antibodies)-mediated astrocytic glutamate (show GRIN1 Antibodies) activates the synaptic N-methyl-D-aspartate receptor (show GRIN1 Antibodies) (NMDAR (show GRIN1 Antibodies)) and modulates NMDAR (show GRIN1 Antibodies)-dependent synaptic plasticity.
Data suggest a role for GluN2A in ethanol tolerance.
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
N-methyl-D-aspartate receptor subunit NR2A
, glutamate receptor, ionotropic, N-methyl D-aspartate 2A
, glutamate [NMDA] receptor subunit epsilon-1-like
, N-methyl D-aspartate receptor subtype 2A
, N-methyl-D-aspartate receptor channel, subunit epsilon-1
, N-methyl-D-aspartate receptor subunit 2A
, NMDA receptor subtype 2A
, glutamate [NMDA] receptor subunit epsilon-1
, glutamate receptor ionotropic, NMDA 2A
, glutamate [NMDA] receptor subunit epsilon 1
, glutamate receptor, ionotropic, N-methyl-D-aspartate subunit 2A