|Application / Reactivity||Human|
|Activation (Act)||3 Antibodies|
|Biochemical Assay (BCA)||6 Antibodies|
|Blocking Antibody (Inhibition)||1 Antibodies|
|Blocking Reagent (BR)||9 Antibodies|
|Complement Mediated Cell Depletion (CMCD)||2 Antibodies|
|Depletion (Dep)||4 Antibodies|
|ELISA (Capture)||1 Antibodies|
|ELISA (Detection)||1 Antibodies|
|ELISpot (Detection) (ELISPOT (Detection))||1 Antibodies|
|Enzyme Immunoassay (EIA)||6 Antibodies|
|Flow Cytometry (FACS)||570 Antibodies|
|Functional Studies (Func)||31 Antibodies|
|Immunochromatography (IC)||3 Antibodies|
|Immunocytochemistry (ICC)||38 Antibodies|
|Immunofluorescence (IF)||92 Antibodies|
|Antigen||CD4 Molecule (CD4) Antibodies|
|Conjugate||This CD4 antibody is conjugated to Alexa Fluor 488 Alternatives|
|5 references available|
|Supplier||Log in to see|
Product Details anti-CD4 AntibodyTarget Details CD4 Application Details Handling References for anti-CD4 Antibody (ABIN2657417) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 488 under optimal conditions.|
Target Details CD4Product Details anti-CD4 Antibody Application Details Handling References for anti-CD4 Antibody (ABIN2657417) Images back to top
|Alternative Name||CD4 (CD4 Antibody Abstract)|
|Background||CD4, also known as T4, is a 55 kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16.|
|Research Area||Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-CD4 Antibody Target Details CD4 Handling References for anti-CD4 Antibody (ABIN2657417) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD4 Antibody Target Details CD4 Application Details References for anti-CD4 Antibody (ABIN2657417) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C|
References for anti-CD4 Antibody (ABIN2657417)Product Details anti-CD4 Antibody Target Details CD4 Application Details Handling Images back to top
Arnó, Ruiz, Juan et al.: "Efficacy of low-dose subcutaneous interleukin-2 to treat advanced human immunodeficiency virus type 1 in persons with =250/microL CD4 T cells and undetectable plasma virus load." in: The Journal of infectious diseases, Vol. 180, Issue 1, pp. 56-60, 1999 (PubMed).
Muench, Roncarolo, Namikawa: "Phenotypic and functional evidence for the expression of CD4 by hematopoietic stem cells isolated from human fetal liver." in: Blood, Vol. 89, Issue 4, pp. 1364-75, 1997 (PubMed).
Center, Kornfeld, Cruikshank: "Interleukin 16 and its function as a CD4 ligand." in: Immunology today, Vol. 17, Issue 10, pp. 476-81, 1997 (PubMed).
Gaubin, Autiero, Houlgatte et al.: "Molecular basis of T lymphocyte CD4 antigen functions." in: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, Vol. 34, Issue 9, pp. 723-8, 1997 (PubMed).
Evans, Wall, Platsoucas et al.: "Thymus-dependent membrane antigens in man: inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, Issue 1, pp. 544-8, 1981 (PubMed).
ImagesProduct Details anti-CD4 Antibody Target Details CD4 Application Details Handling References for anti-CD4 Antibody (ABIN2657417) back to top