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anti-Mouse (Murine) ICOS antibody for ELISA (Capture)

Recommended ICOS Antibody (supplied by: Log in to see )

Antigen
Inducible T-Cell Co-Stimulator (ICOS) Antibodies
  • AILIM
  • Ailim
  • CCLP
  • CD278
  • CRP-1
  • CVID1
  • H4
  • ICOS
  • Ly115
Reactivity
Mouse (Murine)
61
56
42
1
Host
Hamster
34
24
13
10
2
1
Clonality
Monoclonal
Conjugate
This ICOS antibody is conjugated to PE-Cy5
10
8
7
5
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA (Capture), Mass Cytometry (CyTOF)
44
15
14
11
10
7
5
4
4
4
3
3
2
2
2
1
Supplier
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Catalog No. ABIN2658951
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Top referenced anti-ICOS antibody for ELISA (Capture)

Similar anti-ICOS Antibodies

Application / Reactivity Mouse (Murine)
Activation (Act) 2 Antibodies
Blocking Reagent (BR) 3 Antibodies
ELISA 2 Antibodies
ELISA (Capture) 1 Antibodies
ELISA (Detection) 4 Antibodies
Flow Cytometry (FACS) 32 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 7 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 5 Antibodies
Immunoprecipitation (IP) 4 Antibodies
Intracellular Flow Cytometry (ICFC) 4 Antibodies
Mass Cytometry (CyTOF) 1 Antibodies
Western Blotting (WB) 9 Antibodies

General

Antigen Inducible T-Cell Co-Stimulator (ICOS) Antibodies
Reactivity Mouse (Murine)
(61), (56), (42), (1)
Host Hamster
(34), (24), (13), (10), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This ICOS antibody is conjugated to PE-Cy5
(10), (8), (7), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA (Capture), Mass Cytometry (CyTOF)
(44), (15), (14), (11), (10), (7), (5), (4), (4), (4), (3), (3), (2), (2), (2), (1)
Pubmed 6 references available
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Product Details anti-ICOS Antibody

Target Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN2658951) Images
Purification The antibody was purified by affinity chromatography, and conjugated with PE/Cy5 under optimal conditions. The solution is free of unconjugated PE/Cy5 and unconjugated antibody.
Clone 15F9
Isotype IgG

Target Details ICOS

Product Details anti-ICOS Antibody Application Details Handling References for anti-ICOS Antibody (ABIN2658951) Images back to top
Antigen
Alternative Name CD278 (ICOS Antibody Abstract)
Background CD278 is a 47-57 kD protein, also known as inducible costimulatory molecule (ICOS), or H4. This protein is homologous to the CD28/CTLA-4 proteins. It forms homodimers and is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. It has also been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.
Pathways TCR Signaling

Application Details

Product Details anti-ICOS Antibody Target Details ICOS Handling References for anti-ICOS Antibody (ABIN2658951) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-ICOS Antibody Target Details ICOS Application Details References for anti-ICOS Antibody (ABIN2658951) Images back to top
Concentration 0.2 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-ICOS Antibody (ABIN2658951)

Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling Images back to top
Background publications

Beus, Hashmi, Selvaraj, Duan, Stempora, Monday, Cheeseman, Hamby, Speck, Larsen, Kirk, Kean: "Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection." in: PLoS ONE, Vol. 8, Issue 8, pp. e71221, 2013

Mak, Shahinian, Yoshinaga, Wakeham, Boucher, Pintilie, Duncan, Gajewska, Gronski, Eriksson, Odermatt, Ho, Bouchard, Whorisky, Jordana, Ohashi, Pawson, Bladt, Tafuri: "Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses." in: Nature immunology, Vol. 4, Issue 8, pp. 765-72, 2003

Rudd, Schneider: "Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling." in: Nature reviews. Immunology, Vol. 3, Issue 7, pp. 544-56, 2003

Walker, Wiggett, Gaspal, Raykundalia, Goodall, Toellner, Lane: "Established T cell-driven germinal center B cell proliferation is independent of CD28 signaling but is tightly regulated through CTLA-4." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 91-8, 2002

Dong, Juedes, Temann, Shresta, Allison, Ruddle, Flavell: "ICOS co-stimulatory receptor is essential for T-cell activation and function." in: Nature, Vol. 409, Issue 6816, pp. 97-101, 2001

McAdam, Chang, Lumelsky, Greenfield, Boussiotis, Duke-Cohan, Chernova, Malenkovich, Jabs, Kuchroo, Ling, Collins, Sharpe, Freeman: "Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 9, pp. 5035-40, 2000

Images

Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN2658951) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-ICOS antibody (Inducible T-Cell Co-Stimulator)  (PE-Cy5) (ABIN2658951) anti-Inducible T-Cell Co-Stimulator (ICOS) antibody (PE-Cy5)