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anti-Sheep (Ovine) TGFB1 antibody for Functional Studies

Recommended TGFB1 Antibody (supplied by: Log in to see )

Antigen
Transforming Growth Factor, beta 1 (TGFB1) Antibodies
  • ai39657
  • betaig-h3
  • bigh3
  • cdb1
  • cdg2
  • cdgg1
  • CED
  • ced
  • csd
  • csd1
  • csd2
  • csd3
  • DPD1
  • dpd1
  • ebmd
  • LAP
  • lap
  • lcd1
  • MGC146225
  • tgf
  • TGF-beta
  • tgf-beta
  • TGF-BETA-1
  • TGF-beta1
  • TGF-beta5
  • TGFB
  • Tgfb
  • tgfb
  • Tgfb-1
  • tgfb1
  • TGFB1
  • TGFB4
  • tgfb5
  • TGFbeta
  • tgfbeta
  • TGFbeta1
  • TGFBI
  • wu:fb13a07
  • xx:ai39657
Reactivity
Human, Sheep (Ovine)
272
75
63
24
13
13
11
10
7
5
4
3
3
3
3
1
1
Host
Mouse
230
117
5
4
3
2
1
Clonality
Monoclonal
Conjugate
This TGFB1 antibody is un-conjugated
33
23
11
9
9
4
4
3
3
3
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
201
194
98
53
39
33
31
26
26
17
14
10
3
3
2
2
2
2
2
1
1
Supplier
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Catalog No. ABIN114558
$ 522.50
Plus shipping costs $45.00

Top referenced anti-TGFB1 antibody for Functional Studies

Similar anti-TGFB1 Antibodies

Application / Reactivity Sheep (Ovine) Human
ELISA 2 Antibodies 145 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 11 Antibodies
Functional Studies (Func) 1 Antibodies 4 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunofluorescence (IF) 1 Antibodies
Immunohistochemistry (IHC) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 2 Antibodies
Immunoprecipitation (IP) 1 Antibodies
Western Blotting (WB) 3 Antibodies
Agonist (Agon) 2 Antibodies
Blocking Antibody (Inhibition) 1 Antibodies
ELISA (Capture) 1 Antibodies
Flow Cytometry (FACS) 52 Antibodies

General

Antigen Transforming Growth Factor, beta 1 (TGFB1) Antibodies
Reactivity Human, Sheep (Ovine)
(272), (75), (63), (24), (13), (13), (11), (10), (7), (5), (4), (3), (3), (3), (3), (1), (1)
Host Mouse
(230), (117), (5), (4), (3), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TGFB1 antibody is un-conjugated
(33), (23), (11), (9), (9), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(201), (194), (98), (53), (39), (33), (31), (26), (26), (17), (14), (10), (3), (3), (2), (2), (2), (2), (2), (1), (1)
Pubmed 4 references available
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Product Details anti-TGFB1 Antibody

Target Details TGFB1 Application Details Handling References for anti-TGFB1 Antibody (ABIN114558) Images
Specificity This antibody detects Transforming Growth Factor beta/TGF beta.
Purification Affinity Chromatography on Protein G.
Immunogen TGF-beta from Human platelets.
Clone TB21
Isotype IgG1

Target Details TGFB1

Product Details anti-TGFB1 Antibody Application Details Handling References for anti-TGFB1 Antibody (ABIN114558) Images back to top
Antigen
Alternative Name TGFB1 (TGFB1 Antibody Abstract)
Background TGF beta 1 (Transforming Growth Factor Beta 1) is a multifunctional peptide capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed as well as non neoplastic tissues, release transforming growth factors, and essentially all cells possess a specific TGF beta 1 receptor. The multimodal nature of TGF beta 1 is seen in its ability to stimulate or inhibit cellular proliferation. TGF beta 1 plays a fundamental role in tissue growth and differentiation involvement in adipogenesis, myogenesis, chondrogenesis, osteogenesis, epithelial cell differentiation and immune cell function. The C-terminal 112 amino acids constitute the mature protein.Synonyms: TGF-beta-1, TGFB, Transforming growth factor beta-1
Gene ID 7040
NCBI Accession NP_000651
UniProt P01137
Pathways TCR Signaling, ACE Inhibitor Pathway, EGFR Signaling Pathway

Application Details

Product Details anti-TGFB1 Antibody Target Details TGFB1 Handling References for anti-TGFB1 Antibody (ABIN114558) Images back to top
Application Notes ELISAThis antibody recognizes both Human platelet-derived and recombinant TGF-beta in ELISA. Functional AssayThis antibody neutralizes TGF-beta activity in vitro, in an inhibition assay of CCL/64 cellgrowth and neutralizes the growth promoting action of TGF-beta in the NRK-49F colonyforming assay. The effect of micro-injection of this antibody into one blastomere of two cellstage Xenopus embryos indicated that it was able to neutralize effectively the bioactivity ofTGF-beta in vivo. Immunohistochemistry on FFPE and Frozen SectionsThis antibody has been used to demonstrate TGF-beta in ovine ovarian tissue and humanbreast carcinoma at a dilution of 1: 1000. As a consequence of the intense staining of theerythrocytes it is possible to locate a single cell within the ovarian stroma making it usefulin locating very fine capillary networks within tissue. Western Blotting5-20 ng/mL will allow visualization of 100 ng/lane of TGF-beta. Reacts with dimeric (25 Kd)
Restrictions For Research Use only

Handling

Product Details anti-TGFB1 Antibody Target Details TGFB1 Application Details References for anti-TGFB1 Antibody (ABIN114558) Images back to top
Reconstitution Restore in 0.5 mL double distilled water.
Concentration 1.0 mg/mL
Buffer 0.01 M PBS, pH 7.0 without preservatives.
Preservative Without preservative
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Store the antibody at 2 - 8 °C. DO NOT FREEZE!

References for anti-TGFB1 Antibody (ABIN114558)

Product Details anti-TGFB1 Antibody Target Details TGFB1 Application Details Handling Images back to top
Product cited in:

Moesgaard, Aupperle, Rajamäki, Falk, Rasmussen, Zois, Olsen: "Matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and transforming growth factor-? (TGF-?) in advanced canine myxomatous mitral valve disease." in: Research in veterinary science, Vol. 97, Issue 3, pp. 560-7, 2015

Bukowska, Lendeckel, Krohn, Keilhoff, ten Have, Neumann, Goette: "Atrial fibrillation down-regulates renal neutral endopeptidase expression and induces profibrotic pathways in the kidney." in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Vol. 10, Issue 10, pp. 1212-7, 2008

Aupperle, März, Thielebein, Schoon: "Expression of transforming growth factor-beta1, -beta2 and -beta3 in normal and diseased canine mitral valves." in: Journal of comparative pathology, Vol. 139, Issue 2-3, pp. 97-107, 2008

Background publications

Crawford, Stellmach, Murphy-Ullrich, Ribeiro, Lawler, Hynes, Boivin, Bouck: "Thrombospondin-1 is a major activator of TGF-beta1 in vivo." in: Cell, Vol. 93, Issue 7, pp. 1159-70, 1998