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Mammalian PCNA ELISA Kit for Sandwich ELISA - ABIN2344925
Han, Wang, Cong, Gu, Ma, Chi: Therapeutic value of nerve growth factor in promoting neural stem cell survival and differentiation and protecting against neuronal hearing loss. in Molecular and cellular biochemistry 2017
Results show that regulation of e2f1 and PCNA by DREF in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A
We observed that SUUR chromosomal localization changed along with PCNA pattern and these proteins largely co-localized during the late S-phase in salivary glands.
E2F (show E2F2 ELISA Kits) regulation of PCNA is dispensable for viability, but is nonetheless important for normal Drosophila development.
A Q123V mutation dramaticly enhances the abilities of Drosophila PCNA to stimulate calf thymus pol delta (show POLD1 ELISA Kits). Replacing the entire interdomain connector loop AA 119-133 with the corresponding residues from human PCNA results in additional enhancement.
tomato DDI2 gene is required for UV-induced DNA damage repair and plant tolerance to UV stress. [DDI2]
PCNA expression significantly associated with clinical stage, histological grade, and poor prognosis of Osteosarcoma, which could evaluate tumor cell proliferation, and predict its biological behavior and prognosis.
High PCNA expression is associated with lung adenocarcinoma.
Eco1 (show ESCO1 ELISA Kits) mediated acetylation regulates PCNA sliding on DNA in the presence of DNA damage, favoring homologous recombination linked to sister-chromatid cohesion.
Damage-induced fork reversal in mammalian cells requires PCNA ubiquitination, UBC13, and K63-linked polyubiquitin chains, previously involved in error-free damage tolerance. Fork reversal in vivo also requires ZRANB3 translocase activity and its interaction with polyubiquitinated PCNA, pinpointing ZRANB3 as a key effector of error-free DNA damage tolerance.
Multiple studies provide evidence that PCNA lies at the center of the faithful duplication of eukaryotic genomes and therefore genome integrity. [review]
Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp.
Results suggest that the UNG2 N-terminus may serve as a flexible scaffold to tether PCNA and RPA at the replication fork, and that post-translational modifications on the UNG2 N-terminus disrupt formation of the PCNA-UNG2-RPA protein complex.
ECRG2 (show SPINK7 ELISA Kits) in combination with cisplatin (DDP (show TIMM8A ELISA Kits)) can inhibit viability and induce apoptosis in esophageal cancer DDP (show TIMM8A ELISA Kits)-resistant cells, possibly via upregulation of p53 (show TP53 ELISA Kits) expression and downregulation of PCNA expression.
Reduced affinity of PCNA(S228I) for specific clients causes subtle cellular defects in undamaged cells which likely contribute to the etiology of PCNA-associated DNA repair disorder (PARD). Analysis of the binding between PCNA and PCNA-interacting proteins (PIPs (show GPRASP1 ELISA Kits)) shows that the S228I change dramatically impairs the majority of these interactions, including that of Cdt1 (show CDT1 ELISA Kits), DNMT1 (show DNMT1 ELISA Kits), PolD3(p66 (show POLD3 ELISA Kits)) and PolD4(p12 (show POLD4 ELISA Kits)).
Data suggest that, during human DNA replication, restricting PCNA (proliferating cell nuclear antigen) to the vicinity of its DNA target site is important; PCNA can be maintained at or near primer/template junctions during DNA synthesis by RPA (show RPA1 ELISA Kits) (replication protein A) or SSB (single-stranded DNA-binding protein (show RPA1 ELISA Kits)); here, the SSB used was from Escherichia coli.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)-regulated apoptosis and the p53 (show TP53 ELISA Kits)/PCNA- and ATM (show ATM ELISA Kits)/ATR (show ATR ELISA Kits)-Chk1 (show CHEK1 ELISA Kits)/2-controlled DNA-damage response pathways.
REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18 (show RAD18 ELISA Kits).
PCNA was mainly localized in decidual-stromal cells.
Luteolin may inhibit tumor angiogenesis and tumor cell proliferation by down-regulation of LFA- 3 and PCNA and up-regulation of ICAM-1 (show ICAM1 ELISA Kits) in tumor tissue of tumor-bearing mice, thereby achieving its anti-tumor effect.
Data suggest Usp1 (ubiquitin specific peptidase 1 (show USP1 ELISA Kits)) down-regulation by autocleavage is critical for Usp1 (show USP1 ELISA Kits) to exert role in DNA interstrand crosslink repair; Usp1 (show USP1 ELISA Kits) role is de-ubiquitination of Pcna and Fancd2 (Fanconi anemia complementation group D2 (show FANCD2 ELISA Kits)).
The aberrant DNA replication mediated by the PCNA-DNA pol-beta (show POLB ELISA Kits) complex induces p53 (show TP53 ELISA Kits)-dependent neuronal cell death
Demonstrate that miR (show MLXIP ELISA Kits)-376a regulates primordial follicle assembly by modulating the expression of Pcna.
while interaction with PCNA was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers
Styrax japonica glycoprotein increased diethylnitrosamine-induced PCNA activity.
This study identifies a critical role for PCNA in adipose tissue development, and for the first time identifies a role of the core DNA replication machinery at the interface between proliferation and differentiation.
The expression of telomerase activity and TERT (show TERT ELISA Kits) in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 ELISA Kits), wee1 (show WEE1 ELISA Kits), p21 (show CDKN1A ELISA Kits), PCNA and cdk2 (show CDK2 ELISA Kits), but only weakly influences cyclin B1 (show CCNB1 ELISA Kits), cyclin B2 (show CCNB2 ELISA Kits) and cyclin E1 (show CCNE1 ELISA Kits) expression.
There is a link between the intestinal detoxification system (CYP1A) & cell renewal system (PCNA). These two processes are inversely correlated in beta-naphthoflavone- exposed fish
residue in PCNA that is essential to support destruction of all CRL4(Cdt2) substrates
CRL4Cdt2 ubiquitin ligase directly associates with pcna through its C-terminal domain.
PCNA monoubiquitylation serves as a molecular gas pedal that controls the speed of replisome movement during S phase.
Immunodepletion of Swift PAX-interacting protein 1 (show PAXIP1 ELISA Kits) from Xenopus extracts prevented efficient PCNA ubiquitination
PCNA docking activates the pre-formed Cdt1-Cul4(DDB1) ligase complex. Thus, PCNA functions as a platform for Cdt1 destruction, ensuring efficient and temporally restricted inactivation of a key cell-cycle regulator.
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
, proliferating cell nuclear antigen
, proliferating-cell nuclear antigen
, DNA polymerase delta auxiliary protein
, proliferating cell nuclear antigen subtype1
, proliferating cell nuclear antigen subtype2
, proliferating cell nuclear antigen subtype3
, proliferative cell nuclear antigen