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Human Thyroperoxidase Protein expressed in Escherichia coli (E. coli) - ABIN413833
Kinzfogl, Hangoc, Broxmeyer: Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. in Blood 2011
Mouse (Murine) Thyroperoxidase Protein expressed in Escherichia coli (E. coli) - ABIN1525595
Zhou, Wang, Zhao, Liu, Zhao, Zhang, Shan, Teng: Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice. in Frontiers in cellular neuroscience 2017
Our findings suggest that variants inside or near TPO (show THPO Proteins), ATXN2 (show ATXN2 Proteins) and RASGRP1 (show RASGRP1 Proteins) genes are associated with HT. Identified loci are novel to HT and represent good basis for further exploration of HT susceptibility.
Our study indicated that the prevalence of TPO (show THPO Proteins) mutations was 1% among studied Chinese patients with CH. A novel TPO (show THPO Proteins) variation c.1682C>T/p. T561M was found, thereby expanding the mutational spectrum of the gene.
It is concluded that TPO (show THPO Proteins) 2173A>C polymorphism may be considered as a risk factor for developing autoimmune thyroiditis in patients with allergic rhinitis and asthma and that these patients should regularly be checked for hidden thyroiditis.
TPO (show THPO Proteins) transcripts were present in both normal and breast cancer tissue samples, although the amounts in the latter were reduced. TPO (show THPO Proteins) levels are lower in more advanced cancers.
Biallelic TPO (show THPO Proteins) mutations most commonly underlie severe congenital hypothyroidism.
The results of the study suggest that rs11675434 SNP located near TPO (show THPO Proteins) is associated with the development of Graves ophthalmopathy, especially in males and patients with later age of the disease onset.
Mutations in the TPO (show THPO Proteins) gene are associated with Congenital hypothyroidism and thyroid dyshormonogenesis.
Compound heterozygous mutations in the TPO (show THPO Proteins) gene are associated with congenital hypothyroidism.
Mutations in the genes for thyroglobulin (show TG Proteins) and thyroid peroxidase cause thyroid dyshormonogenesis and autosomal-recessive intellectual disability
Studies suggest that Thyroid Peroxidase autoantibodies in early to mid-pregnancy is associated with concurrent depression and may be predictive of depression in the postpartum period.
Lnk (show SH2B3 Proteins) Deficiency Leads to TPO (show THPO Proteins)-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype
Hearing impairment in hypothyroid dwarf (show POU1F1 Proteins) mice caused by mutations of the thyroid peroxidase gene.
Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO (show THPO Proteins).
A novel hypothyroid dwarfism is due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse.
TPO gene was mapped
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
, thyroid peroxidase-like
, thyroid microsomal antigen
, thyroid peroxidase (332 AA)