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Dysregulation of RGMa plays an important role in the pathology of Parkinson's disease.
Thus, we conclude that RGMa inhibits angiogenesis in vitro and in vivo suggesting that its manipulation would be an efficient therapeutic strategy for pro-angiogenic conditions.
RGMa expression and promoter methylation status are closely related to colorectal cancer genesis and progression.
identification of neogenin (show NEO1 Proteins)-binding site on the repulsive guidance molecule A
The expression of RGMA, RGMB (show RGMB Proteins) and RGMC (show HFE2 Proteins) was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues
Reduced expression of RGMA in breast cancer was associated with breast cancer.
The full-length signal peptides of RGMa is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions.
RGM-A is a unique endogenous inhibitor of leukocyte chemotaxis that limits inflammatory leukocyte traffic
Following central nervous system injury, RGM, a novel, potent axonal growth inhibitor, is present in axonal growth impediments: the mature myelin, choroid plexus, and components of the developing scar.
RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and increased utilization of ActRIIA leads to generation of an enhanced BMP signal
RGMa is involved in Th17-cell-mediated neurodegeneration.
repulsive RGMa-Neogenin (show NEO1 Proteins) interactions drive interneurons into the migratory corridor
Postnatal spiral ganglion neurons retain capacity to send out processes that respond to signals for synaptogenesis, but postnatal RGMa expression appears to be detrimental to regeneration of afferent hair cell innervation and antagonizes synaptogenesis
RGMa inhibits axon growth by phosphorylating CRMP-2 via both Rho-kinase and GSK-3beta signaling pathways.
Strong expression of RGMa, RGMb (show RGMB Proteins) and Neogenin (show NEO1 Proteins) protein was found on several major axon tracts such as the primary olfactory projections, anterior commissure and fasciculus retroflexus.
RGMa enhances CD4 (show CD4 Proteins)+ T cell activation facilitating central nervous system intervention in an animal model of multiple sclerosis presented in this review.
Loss-of-function analysis in mice revealed that RGMa may play a more important role in neural tube morphogenesis.
activated microglia play a major role in inhibiting axon regeneration via RGMa
This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants.
repulsive guidance molecule A