Browse our STK3 Proteins (STK3)

Full name:
serine/threonine Kinase 3 Proteins (STK3)
On www.antibodies-online.com are 19 serine/threonine Kinase 3 (STK3) Proteins from 8 different suppliers available. Additionally we are shipping STK3 Antibodies (90) and many more products for this protein. A total of 124 STK3 products are currently listed.
Synonyms:
0610042I06Rik, KRS1, mess1, MST, mst2, Mst3, Ste20, wu:fc19e11, xstk3, zgc:55383
list all proteins Gene Name GeneID UniProt
STK3 6788 Q13188
STK3 56274 Q9JI10
STK3 65189 O54748

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STK3 Proteins (STK3) by Origin

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Human serine/threonine Kinase 3 (STK3) interaction partners

  1. These findings reveal a novel layer of regulation for MST2 in mitosis and its role in tumorigenesis.

  2. TNFAIP8 regulates Hippo (MST1/2) signaling through its interaction with LATS1.

  3. Data suggest that Hippo (MST1 (show MST1 Proteins)/2 protein kinases) - Yes associated protein 1 (YAP (show YAP1 Proteins)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.

  4. H-ras (show HRAS Proteins), via an Erk (show EPHB2 Proteins)-dependent mechanism, downregulates Mst1 (show MST1 Proteins)/Mst2 activity by inducing the formation of inactive Mst1 (show MST1 Proteins)/Mst2 heterodimers.

  5. Results show that STK3 is targeted by Casp6 (show CASP6 Proteins) and demonstrate that alterations in STK3 protein expression levels and post-translational modifications are detected in a cellular model of HD and caspase (show CASP3 Proteins)-mediated generation of STK3 fragments observed under conditions of stress in cells expressing mhtt.

  6. using an Mst2 mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 (show SAV1 Proteins) refolded under acidic pH.

  7. The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.

  8. These results suggest that AIF (show AIFM1 Proteins) downregulation is a common event in kidney tumor development. AIF (show AIFM1 Proteins) loss may lead to decreased STK3 activity, defective apoptosis and malignant transformation

  9. Hippo and Yap (show YAP1 Proteins) regulate cardiomyocyte death and regeneration.

  10. results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart

Mouse (Murine) serine/threonine Kinase 3 (STK3) interaction partners

  1. Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 (show MST1 Proteins) and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (show YAP1 Proteins) target genes and hepatocyte proliferation.

  2. Studies indicate that Hippo (Hpo (show GFER Proteins); MST1 (show MST1 Proteins)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.

  3. Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (show NFKB1 Proteins) pathway

  4. the TLR-Mst1 (show MST1 Proteins)-Mst2-Rac (show AKT1 Proteins) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity

  5. These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (show STK4 Proteins) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy

  6. Phosphorylation of LC3 (show MAP1LC3A Proteins) by the STK3 (show PKN1 Proteins) and STK4 is essential for autophagy.

  7. These results identify MST2, not MST1 (show MST1 Proteins), as a critical regulator of caspase (show CASP3 Proteins)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.

  8. results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart

  9. Mst1 (show MST1 Proteins)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (show MST1 Proteins)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.

  10. results showed that Mst1 (show MST1 Proteins)/Mst2 are required for proper cardiac lineage cell development and teratoma (show DND1 Proteins) formation.

STK3 Protein Profile

Protein Summary

This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with STK3

  • serine/threonine kinase 3 (STK3)
  • serine/threonine kinase 3 (Stk3)
  • serine/threonine kinase 3 (stk3)
  • serine/threonine kinase 3 (STE20 homolog, yeast) (stk3)
  • 0610042I06Rik protein
  • KRS1 protein
  • mess1 protein
  • MST protein
  • mst2 protein
  • Mst3 protein
  • Ste20 protein
  • wu:fc19e11 protein
  • xstk3 protein
  • zgc:55383 protein

Protein level used designations for STK3

MST-2 , STE20-like kinase MST2 , mammalian STE20-like protein kinase 2 , serine/threonine kinase 3 (STE20 homolog, yeast) , serine/threonine kinase 3 (Ste20, yeast homolog) , serine/threonine-protein kinase 3 , serine/threonine-protein kinase Krs-1 , protein kinase homolog , serine/threonine kinase 3 (STE20 homolog)

GENE ID SPECIES
100060508 Equus caballus
6788 Homo sapiens
56274 Mus musculus
65189 Rattus norvegicus
432210 Xenopus laevis
425375 Gallus gallus
533815 Bos taurus
475045 Canis lupus familiaris
100524741 Sus scrofa
324125 Danio rerio
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