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|Application / Reactivity||Human||Rat (Rattus)||Mouse (Murine)|
|Immunofluorescence (fixed cells) (IF/ICC)||1 Antibodies||1 Antibodies|
|Cytometry by Time of Flight (CyTOF)||1 Antibodies|
|Western Blotting (WB)||61 Antibodies||48 Antibodies||16 Antibodies|
|Immunoprecipitation (IP)||2 Antibodies||4 Antibodies||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||13 Antibodies||11 Antibodies||8 Antibodies|
|Immunohistochemistry (IHC)||35 Antibodies||15 Antibodies||7 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||29 Antibodies||29 Antibodies||29 Antibodies|
|Antigen||Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) Antibodies|
|Epitope||Internal Region Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This LRP5 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|1 reference available|
|Supplier||Log in to see|
Product Details anti-LRP5 AntibodyTarget Details LRP5 Application Details Handling References for anti-LRP5 Antibody (ABIN374570) Images
|Specificity||This antibody recognizes LRP5.|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purification||Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide|
|Immunogen||Peptide with sequence C-ERVEKTTGDKRT, from the internal region of the protein sequence Genename: LRP5|
Target Details LRP5Product Details anti-LRP5 Antibody Application Details Handling References for anti-LRP5 Antibody (ABIN374570) Images back to top
|Alternative Name||LRP5 (LRP5 Antibody Abstract)|
|Background||LRP5 is involved in the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Defects in LRP5 are a cause of autosomal dominant and autosomal recessive familial exudative vitreoretinopathy (FEVR). Autosomal dominant FEVR is also referred to as exudative vitreoretinopathy 1 (EVR1), also known as Criswick-Schepens syndrome. FEVR is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. FEVR is reported to have a penetrance of 100 % , but clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease-related abnormality is an arc of avascular retina in the extreme temporal periphery.Synonyms: LRP-5, LRP7, Low-density lipoprotein receptor-related protein 5|
|Gene ID||4041, 9606|
|Research Area||Stem Cells, Wnt, Extracellular Matrix, Wnt Signaling|
|Pathways||WNT Signaling, Stem Cell Maintenance|
Application DetailsProduct Details anti-LRP5 Antibody Target Details LRP5 Handling References for anti-LRP5 Antibody (ABIN374570) Images back to top
Peptide ELISA: Detection Limit: 1/128000. Immunohistochemistry: 3-6 μg/mL. In Paraffin Embedded Human Kidney shows primarily nuclear envelope staining in PCT-.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-LRP5 Antibody Target Details LRP5 Application Details References for anti-LRP5 Antibody (ABIN374570) Images back to top
|Buffer||Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-LRP5 Antibody (ABIN374570)Product Details anti-LRP5 Antibody Target Details LRP5 Application Details Handling Images back to top
He, Semenov, Tamai, Zeng: "LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way." in: Development (Cambridge, England), Vol. 131, Issue 8, pp. 1663-77, 2004
ImagesProduct Details anti-LRP5 Antibody Target Details LRP5 Application Details Handling References for anti-LRP5 Antibody (ABIN374570) back to top