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|Antigen||Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This LRP5 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-LRP5 AntibodyTarget Details LRP5 Application Details Handling Images
|Specificity||This antibody reacts to LRP5.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP5.|
Target Details LRP5Product Details anti-LRP5 Antibody Application Details Handling Images back to top
|Alternative Name||LRP5 (LRP5 Antibody Abstract)|
|Background||Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration. Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes. All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family.Synonyms: LRP-5, LRP7, Low-density lipoprotein receptor-related protein 5|
|Gene ID||4041, 9606|
|Research Area||Stem Cells, Wnt, Extracellular Matrix, Wnt Signaling|
|Pathways||WNT Signaling, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation|
Application DetailsProduct Details anti-LRP5 Antibody Target Details LRP5 Handling Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-LRP5 Antibody Target Details LRP5 Application Details Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
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