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Browse our LRP5 Proteins (LRP5)

Full name:
Low Density Lipoprotein Receptor-Related Protein 5 Proteins (LRP5)
On www.antibodies-online.com are 9 Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) Proteins from 4 different suppliers available. Additionally we are shipping LRP5 Antibodies (119) and LRP5 Kits (8) and many more products for this protein. A total of 140 LRP5 products are currently listed.
Synonyms:
BMND1, EVR1, EVR4, HBM, LR3, LRP5, lrp5-A, LRP6, LRP7, mKIAA4142, OPPG, OPS, OPTA1, VBCH2, Xlrp5
list all proteins Gene Name GeneID UniProt
LRP5 4041 O75197
LRP5 16973 Q91VN0
Rat LRP5 LRP5 293649  

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LRP5 Proteins (LRP5) by Origin

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More Proteins for LRP5 Interaction Partners

Xenopus laevis Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. The extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt (show WNT2 Proteins) signaling during Xenopus and mouse development in vivo.

Zebrafish Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. Data show that in zebrafish, lrp5 also controls cell migration during early morphogenetic processes and contributes to shaping the craniofacial skeleton.

Human Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. LRP5 is a signature of the anti-inflammatory defensive phenotype of macrophages.

  2. we identified a total of four different LRP5 variants that were predicted to be pathogenic by in silico tools. One ADPKD patient has a positive family history for ADPKD and variant LRP5 segregated with the disease.

  3. finding corroborates the relationship between LRP5 genotype and bone phenotype in postmenopausal women, however, the complete mechanism of this relationship requires further investigations.

  4. This study show LRP5 polymorphism may associate with body composition and bone mineral density in Iranian children.

  5. Lrp5 controls glucose uptake and growth of MDA-MB-231 human breast cancer cells.

  6. Data show that LDL receptor (show LDLR Proteins)-related protein 5 (show CAPS Proteins) (LRP5) gain-of-function mutations do not activate beta-catenin (show CTNNB1 Proteins) signaling in osteoblasts.

  7. findings suggest that rescuing LRP5/6-mediated Wnt (show WNT2 Proteins) signaling improves neuronal cell survival and reduces tau phosphorylation, which support the hypothesis that Wnt (show WNT2 Proteins) signaling might be an attractive therapeutic strategy for managing AD

  8. Molecular testing identified biallelic lipoprotein receptor-related protein (show LRP1 Proteins) 5 (show CAPS Proteins) (LRP5) mutations (NM_002335.3:c. [889dupA]; [2827 + 1G > A]) confirming a diagnosis of osteoporosis-pseudoglioma (OPPG) syndrome.

  9. Lrp5 binds to Frizzled, preventing Frz-regulated non-canonical Wnt (show WNT2 Proteins) pathway activation and further non-canonical pathway-mediated tumour metastasis.

  10. Reciprocally, a low bone mineral density-associated common LRP5 allele correlated with increased abdominal adiposity.

Mouse (Murine) Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) interaction partners

  1. These results revealed a new role of the canonical Lrp5/6-beta-catenin (show CTNNB1 Proteins) pathway in regulating the morphogenesis of the cerebellum during postnatal development.

  2. LRP5 function in mice causes retinal hypovascularization during development as well as retinal neovascularization in adulthood with disorganized and leaky vessels.

  3. Lrp5 is required for glucose uptake, and glucose uptake regulates the growth rate of mammary epithelial cells in culture.

  4. Data show that LDL receptor (show LDLR Proteins)-related protein 5 (show CAPS Proteins) (LRP5) gain-of-function mutations do not activate beta-catenin (show CTNNB1 Proteins) signaling in osteoblasts.

  5. These in vivo data support in vitro studies regarding the mechanism of HBM-causing mutations, and imply that HBM LRP5 receptors differ in their relative sensitivity to inhibition by SOST (show SOST Proteins) and DKK1 (show DKK1 Proteins).

  6. Lrp5 A214V and G171V were partially or fully protected from the bone loss that normally results frommechanical disuse using two models, tail suspension and Botulinum toxin-induced muscle paralysis, in two different Lrp5 HBM knock-in mouse models.

  7. In hypercholesterolemia LRP5(-/-) mice Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway was shut down. An antiatherogenic role for LRP5 was demonstrated as HC LRP5(-/-) mice developed larger aortic atherosclerotic lesions than WT mice.

  8. Report accelerated lung regeneration by platelet-rich plasma extract through Lrp5/Tie2 (show TEK Proteins) pathway.

  9. Data show that low density lipoprotein receptor-related protein 5 (LRP5) and the canonical Wnt (show WNT2 Proteins) pathway down-regulation regulate the dyslipidaemic profile by promoting lipid and macrophage retention in the vessel wall.

  10. Lrp5 binds to Frizzled, preventing Frz-regulated non-canonical Wnt (show WNT2 Proteins) pathway activation and further non-canonical pathway-mediated tumour metastasis.

LRP5 Protein Profile

Protein Summary

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.

Alternative names and synonyms associated with LRP5

  • low density lipoprotein receptor-related protein 5 (LRP5)
  • low density lipoprotein receptor-related protein 5 (lrp5)
  • low density lipoprotein receptor-related protein 5 (LOC100220027)
  • low density lipoprotein receptor-related protein 5 (Lrp5)
  • BMND1 protein
  • EVR1 protein
  • EVR4 protein
  • HBM protein
  • LR3 protein
  • LRP5 protein
  • lrp5-A protein
  • LRP6 protein
  • LRP7 protein
  • mKIAA4142 protein
  • OPPG protein
  • OPS protein
  • OPTA1 protein
  • VBCH2 protein
  • Xlrp5 protein

Protein level used designations for LRP5

Lipoprotein Receptor Related Protein 5 , low density lipoprotein receptor-related protein 5 , low-density lipoprotein receptor-related protein 5 , low-density lipoprotein receptor-related protein 5-like , LRP-5 , low density lipoprotein receptor-related protein 7 , LRP-7 , low-density lipoprotein receptor-related protein 7

GENE ID SPECIES
100147353 Equus caballus
100009566 Oryctolagus cuniculus
373722 Xenopus laevis
451380 Pan troglodytes
568518 Danio rerio
100189542 Papio anubis
100220027 Taeniopygia guttata
100406268 Callithrix jacchus
100473379 Ailuropoda melanoleuca
100491803 Xenopus (Silurana) tropicalis
100548748 Meleagris gallopavo
4041 Homo sapiens
16973 Mus musculus
293649 Rattus norvegicus
423114 Gallus gallus
100306933 Canis lupus familiaris
534450 Bos taurus
100524299 Sus scrofa
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