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Lrp6 asymmetry is controlled by Wnt (show WNT2 Proteins)/PCP (show PRCP Proteins) signaling, indicating that this pathway regulates not only planar- but also apicobasal cell polarity.
PTK7 (show PTK7 Proteins) and LRP6 proteins physically interact, suggesting that PTK7 (show PTK7 Proteins) stabilization of LRP6 protein reciprocally regulates both canonical and noncanonical Wnt (show WNT2 Proteins) activities in the embryo.
Results suggest that Rap2 (show RAP2A Proteins) acts via TNIK (show TNIK Proteins) to regulate the stability of LRP6 receptor for Wnt (show WNT2 Proteins) signaling.
The extracellular domains of Lrp5 (show LRP5 Proteins)/6 behave as physiologically relevant inhibitors of noncanonical Wnt (show WNT2 Proteins) signaling during Xenopus and mouse development in vivo.
Lrp6 plays a critical role in the switch from Wnt (show WNT2 Proteins)/PCP (show PRCP Proteins) to Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Kremen2 (show KREMEN2 Proteins) knockdown specifically reduces LRP6 protein levels in neural crest explants.
Waif1a binds to the Wnt (show WNT2 Proteins) coreceptor LRP6 (show LRP5 Proteins) and inhibits Wnt (show WNT2 Proteins)-induced LRP6 (show LRP5 Proteins) internalization into endocytic vesicles, a process that is required for pathway activation.
Results identify GRK5 (show GRK5 Proteins)/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP5 Proteins) during Wnt (show WNT2 Proteins) signaling.
Accordingly, we propose that the anti-fibrotic activity of adiponectin (show ADIPOQ Proteins) may be mediated through AdipoR1 (show ADIPOR1 Proteins)/R2 receptors
findings suggest that rescuing LRP5 (show LRP5 Proteins)/6-mediated Wnt (show WNT2 Proteins) signaling improves neuronal cell survival and reduces tau phosphorylation, which support the hypothesis that Wnt (show WNT2 Proteins) signaling might be an attractive therapeutic strategy for managing AD
Results suggest that miR (show MLXIP Proteins)-126 functions as a tumor-suppressive miRNA by targeting LRP6 regulating Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway in papillary thyroid carcinoma.
miR513c functions as a tumor suppressor miRNA, mediated predominantly through the direct suppression of the expression of LRP6.
The interaction between Wnt (show WNT2 Proteins) isoforms and their LRP6 cognate receptor depends on the jutting loop present in Wnt3a (show WNT3A Proteins) but absent in Wnt5b (show WNT5B Proteins).
LRP6 and VEGF levels in the vitreous body from patients with proliferative diabetic retinopathy were increased and correlated mutually.
Lrp6 (show LRP5 Proteins) binds to Frizzled, preventing Frz-regulated non-canonical Wnt (show WNT2 Proteins) pathway activation and further non-canonical pathway-mediated tumour metastasis.
No mutations in LRP5 (show LRP5 Proteins) and LRP6 could be identified
LRP6 variants may be associated with risk of ischaemic stroke.
Particularly for TNBC associated with Skp2/LRP6 overexpression.
Data (including data from studies in knockout/transgenic mice) suggest Lrp6 is required for suppression of Sost (sclerostin (show SOST Proteins)) expression by parathyroid hormone (show PTH Proteins) (here, human PTH (show PTH Proteins) peptide 1-34); LRP6 regulates osteocytes expression of histone deacetylases.
Lrp5 (show LRP5 Proteins) binds to Frizzled, preventing Frz-regulated non-canonical Wnt (show WNT2 Proteins) pathway activation and further non-canonical pathway-mediated tumour metastasis.
Wt1 (show WT1 Proteins) expression levels in podocytes regulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling through modulating the endocytic fate of LRP6, and this indicates a potential target for the therapy of CKD.
N-cadherin (show CDH2 Proteins) modulates Lrp6/PTHR1 (show PTH1R Proteins) interaction, restraining the intensity of parathyroid hormone (show PTH Proteins)-induced beta-catenin (show CTNNB1 Proteins) signaling
LRP6 restrains vascular smooth muscle lineage noncanonical signals that promote osteochondrogenic differentiation, mediated in part via USF1 (show USF1 Proteins)- and arginine methylation-dependent relays.
Urotensin II (show UTS2 Proteins) inhibited the proliferation of cardiac side population cells by JNK (show MAPK8 Proteins)/LRP6 signalling during pressure overload.
Hgf (show HGF Proteins) as an important transactivator of canonical Wnt (show WNT2 Proteins) signaling that is mediated by Met-stimulated, Gsk3-dependent Lrp5 (show LRP5 Proteins)/6 phosphorylation
miR (show MLXIP Proteins)-183, though negatively regulated by Gata3 (show GATA3 Proteins), enhances 3T3-L1 preadipocyte differentiation and adipogenesis by targeting LRP6.
Phosphorylation of LRP6 was increased after tissue plasminogen activator (tPA (show PLAT Proteins)) treatment and decreased by tPA (show PLAT Proteins) siRNA transfection.
Results indicate that Lrp6 mediates not only canonical Wnt (show WNT2 Proteins) signaling, but can also modulate non-canonical pathways involving RhoA (show RHOA Proteins)-dependent mechanisms to impact neurulation, possibly through intracellular complexes with DAAM1 (show DAAM1 Proteins).
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
low density lipoprotein receptor-related protein 6
, lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6-like
, low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6
, low density lipoprotein-related protein 6