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Browse our ZNRF3 Proteins (ZNRF3)

Full name:
Zinc and Ring Finger Protein 3 Proteins (ZNRF3)
On www.antibodies-online.com are 3 Zinc and Ring Finger Protein 3 (ZNRF3) Proteins from 1 different suppliers available. Additionally we are shipping ZNRF3 Antibodies (16) and many more products for this protein. A total of 20 ZNRF3 products are currently listed.
Synonyms:
AA591877, BC019575, BK747E2.3, Gm1167, RNF203
list all proteins Gene Name GeneID UniProt
Rat ZNRF3 ZNRF3 685487  
ZNRF3 84133 Q9ULT6
Mouse ZNRF3 ZNRF3 407821 Q5SSZ7

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ZNRF3 Proteins (ZNRF3) by Origin

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Human Zinc and Ring Finger Protein 3 (ZNRF3) interaction partners

  1. Report shows that miR (show MLXIP Proteins)-146b participated in migration, invasion and chemoresistance in osteosarcoma via downregulation of ZNRF3.

  2. Data indicate Dishevelled (DVL (show DVL2 Proteins)) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 (show RNF43 Proteins) to Wnt (show WNT2 Proteins) receptors to ensure proper control of pathway activity.

  3. ZNRF3 binds RSPO1 (show RSPO1 Proteins) and LGR5 (show LGR5 Proteins)-RSPO1 (show RSPO1 Proteins) with micromolar affinity via RSPO1 (show RSPO1 Proteins) furin (show FURIN Proteins)-like 1 (Fu1) domain.

  4. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15 (show TBX15 Proteins)/WARS2 (show WARS2 Proteins), STAB1, PIGC (show PIGC Proteins), ZNRF3, GRB14 (show GRB14 Proteins)

  5. Signalling potency of R-spondin proteins depends on their ability to recruit ZNRF3 or RNF43 (show RNF43 Proteins) via Fu1 into a complex with LGR receptors, which interact with Rspo (show RSPO1 Proteins) via Fu2

  6. ZNRF3 inhibits gastric cancer cell growth and promotes cell apoptosis by affecting the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)/TCF4 (show TCF4 Proteins) signalling pathway.

  7. study provides new mechanistic insights (show WNT2 Proteins)into the regulation of Wnt receptor turnover, and reveals ZNRF3 as a tractable target for therapeutic exploration

Mouse (Murine) Zinc and Ring Finger Protein 3 (ZNRF3) interaction partners

  1. Crystal structure confirming that Rspo (show RSPO1 Proteins) proteins cross-link LGRs and ZNRF3 into a 2:2:2 complex.

  2. ZNRF3 binds RSPO1 (show RSPO1 Proteins) and LGR5 (show LGR5 Proteins)-RSPO1 (show RSPO1 Proteins) with micromolar affinity via RSPO1 (show RSPO1 Proteins) furin (show FURIN Proteins)-like 1 (Fu1) domain.

  3. data suggest that R-spondin enhances Wnt (show WNT2 Proteins) signalling by inhibiting ZNRF3

ZNRF3 Protein Profile

Protein Summary

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway.

Alternative names and synonyms associated with ZNRF3

  • zinc and ring finger 3 (Znrf3)
  • zinc and ring finger 3 (ZNRF3)
  • AA591877 protein
  • BC019575 protein
  • BK747E2.3 protein
  • Gm1167 protein
  • RNF203 protein

Protein level used designations for ZNRF3

rCG35969-like , E3 ubiquitin-protein ligase ZNRF3 , RING finger protein 203 , novel C3HC4 type Zinc finger (ring finger) , zinc/RING finger protein 3

GENE ID SPECIES
685487 Rattus norvegicus
416919 Gallus gallus
486339 Canis lupus familiaris
100153654 Sus scrofa
535441 Bos taurus
84133 Homo sapiens
407821 Mus musculus
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