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Data indicate Dishevelled (DVL (show DVL2 Proteins)) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 (show RNF43 Proteins) to Wnt (show WNT2 Proteins) receptors to ensure proper control of pathway activity.
ZNRF3 binds RSPO1 (show RSPO1 Proteins) and LGR5 (show LGR5 Proteins)-RSPO1 (show RSPO1 Proteins) with micromolar affinity via RSPO1 (show RSPO1 Proteins) furin (show FURIN Proteins)-like 1 (Fu1) domain.
Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15 (show TBX15 Proteins)/WARS2 (show WARS2 Proteins), STAB1, PIGC (show PIGC Proteins), ZNRF3, GRB14 (show GRB14 Proteins)
Signalling potency of R-spondin proteins depends on their ability to recruit ZNRF3 or RNF43 (show RNF43 Proteins) via Fu1 into a complex with LGR receptors, which interact with Rspo (show RSPO1 Proteins) via Fu2
ZNRF3 inhibits gastric cancer cell growth and promotes cell apoptosis by affecting the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)/TCF4 (show TCF4 Proteins) signalling pathway.
study provides new mechanistic insights (show WNT2 Proteins)into the regulation of Wnt receptor turnover, and reveals ZNRF3 as a tractable target for therapeutic exploration
Crystal structure confirming that Rspo (show RSPO1 Proteins) proteins cross-link LGRs and ZNRF3 into a 2:2:2 complex.
data suggest that R-spondin enhances Wnt (show WNT2 Proteins) signalling by inhibiting ZNRF3
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway.
, E3 ubiquitin-protein ligase ZNRF3
, RING finger protein 203
, novel C3HC4 type Zinc finger (ring finger)
, zinc/RING finger protein 3