anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Antibodies

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (28) and ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABCB1 5243 P08183
ABCB1 170913  
ABCB1 18669 P06795
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Top anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antibodies at antibodies-online.com

Showing 10 out of 257 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (fro), IHC (p) Anti-P Glycoprotein Picoband antibody,  IHC(P): Mouse Kidney Tissue Anti-P Glycoprotein Picoband antibody,  IHC(F): Rat Kidney Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-ABCB1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  NCI-H226 cell lysate 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Mouse Un-conjugated IHC Immunohistochemistry: MDR1/ABCB1 Antibody (1A7) [NBP2-46466] - Analysis of Adenocarcinoma of Human breast tissue. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min) Immunohistochemistry: MDR1/ABCB1 Antibody (1A7) [NBP2-46466] - Analysis of Carcinoma of Human pancreas tissue. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Mouse Un-conjugated IHC, IHC (p) 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6268733 for IHC in human brain tissue Western blot analysis of MDR1 using HT-29 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Dog Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 8 to 11 Days
$619.30
Details
Human Rabbit Un-conjugated ELISA, WB Western blot using  affinity purified anti-ABCB1 antibody shows detection of ABCB1 in crude membrane extracts from HF insect cells over-expressing human ABCB1. The extract was loaded onto a gel in the amounts indicated followed by electrophoresis and transfer to nitrocellulose. The membrane was probed with the primary antibody diluted to 1:600, followed by Peroxidase Conjugated Affinity Purified Anti-RABBIT IgG at 1:10,000. Personal Communication, Anna Calcagno, CCR-NCI, Bethesda, MD. IHC using  ABCB1 Antibody at 20 ug/ml against FFPE human kidney. Moderate to strong cytoplasmic and membranous staining seen in this example. Similar staining also observed in other tissues including liver, kidney, and small intestine. The antibody showed minimal background staining and worked well in formalin-fixed tissues. Image provided courtesy of Lifespan Biosciences. 100 μg Log in to see 5 to 7 Days
$583.50
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: MDR1/ABCB1 Antibody [NBP1-90291] - Immunohistochemical staining of human liver shows cytoplasmic positivity in hepatocytes. Immunohistochemistry-Paraffin: MDR1/ABCB1 Antibody  - Staining of human liver shows cytoplasmic positivity in hepatocytes. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Mouse Un-conjugated ICC, IHC (fro), IHC (p), WB   100 μg Log in to see 4 to 6 Days
$280.00
Details

Top referenced anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antibodies

  1. Human Polyclonal ABCB1 Primary Antibody for IHC (fro), IHC (p) - ABIN3043967 : Gao, Liu, Wang, Lin, Zhang: Effects of Lewis Y antigen on the gene expression of multiple drug resistance-associated proteins in human ovarian cancer RMG-I-H cells. in Medical oncology (Northwood, London, England) 2010 (PubMed)
    Show all 30 Pubmed References

  2. Human Polyclonal ABCB1 Primary Antibody for ELISA, IHC - ABIN6263928 : Zhou, Lin, Zhang, Zhang, Zhang, Zhang, Xie, Ren: miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression. in Cell proliferation 2017 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal ABCB1 Primary Antibody for IHC (fro), FACS - ABIN2479419 : Mechetner, Roninson: Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 4 Pubmed References

  4. Human Monoclonal ABCB1 Primary Antibody for FACS - ABIN2479421 : Beck, Grogan, Willman, Cordon-Cardo, Parham, Kuttesch, Andreeff, Bates, Berard, Boyett, Brophy, Broxterman, Chan, Dalton, Dietel, Fojo, Gascoyne, Head, Houghton, Srivastava, Lehnert, Leith, Paietta et al.: Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations. ... in Cancer research 1996 (PubMed)
    Show all 4 Pubmed References

  5. Human Monoclonal ABCB1 Primary Antibody for FACS - ABIN2479422 : Koziolek, Riess, Geiger, Thévenod, Hauser: Expression of multidrug resistance P-glycoprotein in kidney allografts from cyclosporine A-treated patients. in Kidney international 2001 (PubMed)
    Show all 4 Pubmed References

  6. Human Monoclonal ABCB1 Primary Antibody for FACS - ABIN2479424 : Park, Lomri, Simeoni, Fruehauf, Mechetner: Analysis of P-glycoprotein-mediated membrane transport in human peripheral blood lymphocytes using the UIC2 shift assay. in Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003 (PubMed)
    Show all 4 Pubmed References

  7. Human Monoclonal ABCB1 Primary Antibody for ELISA, WB - ABIN1724927 : Zhang, Wang, Cai, Jiang, Zhou, Yang, Chen, Chen, Dou: Downregulation of gene MDR1 by shRNA to reverse multidrug-resistance of ovarian cancer A2780 cells. in Journal of cancer research and therapeutics 2012 (PubMed)
    Show all 2 Pubmed References

  8. Human Monoclonal ABCB1 Primary Antibody for ELISA, WB - ABIN1724923 : Rubi?, Ho?ysz, Barczak, Gryczka, ?aci?ski, Jagielski, Czernikiewicz, Pó?rolniczak, Wojewoda, Perz, Bia?ek, Morze, Kandu?a, Lisiak, Mrozikiewicz, Grodecka-Gazdecka, Rybczy?ska: Study of ABCB1 polymorphism frequency in breast cancer patients from Poland. in Pharmacological reports : PR 2013 (PubMed)
    Show all 2 Pubmed References

  9. Human Polyclonal ABCB1 Primary Antibody for IHC, IHC (p) - ABIN4333368 : Bernstein, Hölzl, Dobrowolny, Hildebrandt, Trübner, Krohn, Bogerts, Pahnke: Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary. in Mechanisms of ageing and development 2015 (PubMed)
    Show all 2 Pubmed References

  10. Human Monoclonal ABCB1 Primary Antibody for ICC, IHC (fro) - ABIN3043101 : Wang, Deng, Lu, Xu, Yan, Ye, Chen et al.: Gambogic acid as a non-competitive inhibitor of ATP-binding cassette transporter B1 reverses the multidrug resistance of human epithelial cancers by promoting ATP-binding cassette transporter B1 ... in Basic & clinical pharmacology & toxicology 2012 (PubMed)
    Show all 2 Pubmed References

More Antibodies against ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Interaction Partners

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. MDR1 (show TBC1D9 Antibodies) is not expressed on erythrocyte membrane.

  2. The genetic polymorphisms of the multi-drug resistance-1 (MDR-1 (show TBC1D9 Antibodies)) and human cytochrome P450 (show CYP Antibodies) 3A (CYP3A4 (show CYP3A4 Antibodies) and CYP3A5 (show CYP3A5 Antibodies)) genes were analyzed and compared between steroid sensitive, steroid resistant and control groups.

  3. This meta-analysis suggests that the MDR1 (show TBC1D9 Antibodies) C > T polymorphism was not associated with the risk of MM. To confirm these findings, further comprehensive and well-designed studies are needed.

  4. High MDR1 (show TBC1D9 Antibodies) expression is associated with chemoresistance in ovarian cancer.

  5. 13-cis (show CISH Antibodies)-retinoic acid, retinol and retinyl-acetate inhibited the Pgp (show PGPEP1 Antibodies) and ABCG2 mediated substrate transport as well as the substrate stimulated ATPase (show DNAH8 Antibodies) activity of these transporters.

  6. Haplotype analysis of ABCB1 conducted in patients with bullous pemphigoid (show DST Antibodies) demonstrated that the 1236T-2677G-3435T haplotype may protect against development of disease.

  7. High ABCB1 expression is associated with Bendamustine-resistance in Mantle Cell Lymphoma.

  8. Data show that multidrug resistance gene 1 (MDR1 (show TBC1D9 Antibodies)) expression was associated with worsen survival of esophageal squamous cell carcinoma (ESCC) patients with cisplatin-based chemotherapy.

  9. ABCB1 variation affected myelosuppression, progression-free survival and overall survival in ovarian cancer patients who were treated with paclitaxel and carboplatin

  10. Our data showed that the expression of the MDR1 (show TBC1D9 Antibodies) gene was significantly higher in malignant tissue than in the normal tissues of patients with STS (show STS Antibodies). In addition, high MDR1 (show TBC1D9 Antibodies) expression was significantly associated with local advances, as well as poor response to treatment.

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. P-gp (show ABCB4 Antibodies), Bcrp and Mrp1 (show ABCC1 Antibodies) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. this study shows that MDR1 (show ABCB4 Antibodies) deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

  2. A panel of 18 P-gp (show ABCB4 Antibodies) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (show ABCB4 Antibodies)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (show ABCB4 Antibodies) can affect the pulmonary kinetics of a subset of P-gp (show ABCB4 Antibodies) substrates.

  3. Data suggest that the overexpression of P-gp (show ABCB4 Antibodies) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

  4. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

  5. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (show ABCB4 Antibodies), multi-drug resistance protein, MDR1 (show ABCB4 Antibodies)).Drugs with ER < 1 (show MIER1 Antibodies) almost do not bind the main binding cavity (MBC (show CACNA1C Antibodies)) of P-gp (show ABCB4 Antibodies).

  6. conclusion, MDR1 (show ABCB4 Antibodies) and BCRP are expressed on apical membranes of the rodent placental SynT (show STX1A Antibodies)-II layer.

  7. Mdr1 (show ABCB4 Antibodies) enforces T Cell homeostasis in the presence of intestinal bile acids.

  8. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  9. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (show ABCB4 Antibodies) ATPase (show DNAH8 Antibodies) activity

  10. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Antigen Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1

  • ATP binding cassette subfamily B member 1 (ABCB1) antibody
  • ATP binding cassette subfamily B member 1A (Abcb1a) antibody
  • ATP binding cassette subfamily B member 1 L homeolog (abcb1.L) antibody
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b) antibody
  • ATP binding cassette subfamily B member 1 (Abcb1) antibody
  • ABC20 antibody
  • ABCB1 antibody
  • CD243 antibody
  • CLCS antibody
  • GP170 antibody
  • mdr antibody
  • Mdr1 antibody
  • Mdr1a antibody
  • Mdr1b antibody
  • p-gp antibody
  • PGP1 antibody
  • Pgy-1 antibody
  • Pgy1 antibody
  • xemdr antibody

Protein level used designations for ABCB1

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , bovine P-glycoprotein , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B

GENE ID SPECIES
5243 Homo sapiens
170913 Rattus norvegicus
281585 Bos taurus
403879 Canis lupus familiaris
397812 Xenopus laevis
463516 Pan troglodytes
18669 Mus musculus
100682536 Cricetulus griseus
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