ABCB1 antibody (AA 600-700)
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- Target See all ABCB1 Antibodies
- ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
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Binding Specificity
- AA 600-700
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ABCB1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Sequence
- GFDDGVIVEK GNHDELMKEK GIYFKLVTMQ TAGNEVELEN AADESKSEID ALEMSSNDSR SSLIRKRSTR RSVRGSQAQD RKLSTKEALD ESIPPVSFWR I
- Cross-Reactivity
- Human, Mouse
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- A synthetic peptide corresponding to a sequence within amino acids 600-700 of human P Glycoprotein (NP_000918.2).
- Isotype
- IgG
- Top Product
- Discover our top product ABCB1 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000,IF,1:50 - 1:200
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
- Alternative Name
- ABCB1 (ABCB1 Products)
- Synonyms
- ABC20 antibody, CD243 antibody, CLCS antibody, GP170 antibody, MDR1 antibody, P-GP antibody, PGY1 antibody, Abcb1 antibody, Mdr1a antibody, p-gp antibody, xemdr antibody, Mdr1 antibody, Mdr1b antibody, Pgy-1 antibody, Pgy1 antibody, mdr antibody, ABCB1 antibody, PGP1 antibody, ATP binding cassette subfamily B member 1 antibody, ATP binding cassette subfamily B member 1A antibody, ATP binding cassette subfamily B member 1 L homeolog antibody, ATP-binding cassette, sub-family B (MDR/TAP), member 1B antibody, ABCB1 antibody, Abcb1a antibody, abcb1.L antibody, Abcb1b antibody, Abcb1 antibody
- Background
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.,ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,P Glycoprotein,ABCB1,Cancer,Drug resistance,P glycoproteins,Signal Transduction,Endocrine & Metabolism,Immunology & Inflammation,CD markers,Stem Cells,Hematopoietic Progenitors,ABCB1
- Molecular Weight
- 134 kDa/141 kDa
- Gene ID
- 5243
- UniProt
- P08183
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