ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 Proteins (ABCC1)

The protein encoded by ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC1 Antibodies (83) and ABCC1 Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCC1 4363 P33527
ABCC1 17250 O35379
Rat ABCC1 ABCC1 24565 Q8CG09
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Top ABCC1 Proteins at antibodies-online.com

Showing 7 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$816.00
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$1,017.50
Details

ABCC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. These results show that multidrug resistant leukemia cell microparticle regulation of ABCC1 in recipient cells is governed by the transfer of both miR (show MLXIP Proteins)-326 and ABCB1 (show ABCB1 Proteins) from donor cells

  2. Higher expression of ABCG2 and MRP1 (show MDM4 Proteins), and lower expression of CK19 (show KRT19 Proteins) in papillary thyroid carcinomas with a solid component were associated with higher tumor recurrence rate and shorter disease-free survival.

  3. Visfatin (show NAMPT Proteins) increases the nuclear translocation of Akt (show AKT1 Proteins) and its binding with ABCC1. These data showed that visfatin (show NAMPT Proteins) can decrease doxorubicin sensitivity of Non-small-cell lung cancer cells via activation of Akt (show AKT1 Proteins)/MRP1 (show MDM4 Proteins).

  4. Studied hedgehog (show SHH Proteins) signaling effect thru ATP-binding cassette (ABC (show ABCB6 Proteins)) transporters in hepatoma drug sensitivity. Results suggest Hedgehog (show SHH Proteins) signaling transcription factor Gli-2 to be the primary regulator for drug sensitivity of hepatoma through the ABCC1 transporter.

  5. This study demonstrated that mitochondrial MRP-1 (show MDM4 Proteins) is expressed in the outer mitochondrial membrane and is a client protein of HSP90beta (show HSP90AB1 Proteins).

  6. High ABCC1 expression is associated with hepatic fibrosis.

  7. This study shows direct binding between MRP1 (show MDM4 Proteins) Linker 1 (L1MRP1) domain and alpha- and beta-tubulin (show TUBB Proteins) subunits, using a scanning peptide approach

  8. In summary, chaetominine strongly reverses drug resistance by interfering with the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/Nrf2 (show GABPA Proteins) signaling, resulting in reduction of MRP1 (show MDM4 Proteins)-mediated drug efflux and induction of Bax (show BAX Proteins)/Bcl-2 (show BCL2 Proteins)-dependent apoptosis in an ADR (show AKR1B1 Proteins)-resistant K562/Adr (show AKR1B1 Proteins) leukemia cell line.

  9. cross-talk between MRP1 (show MDM4 Proteins) glycosylation and phosphorylation occurs.

  10. meta-analysis results strongly suggest that MRP1 (show MDM4 Proteins) is overexpressed in both neurons and astrocytes of intractable epilepsy patients, inhibition of MRP1 (show MDM4 Proteins) may enhance antiepileptic drug efficacy by increasing local drug availability

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. Loss of ABCC1 expression is associated with neonatal hyperbilirubinemia.

  2. Data, including data from studies in knockout mice, suggest that Mrp1 is involved in development of vascular endothelial dysfunction in diabetic angiopathy; Mrp1 appears to be required for oxidative stress in endothelial cells due to hyperglycemia.

  3. Oxidant-enriched Tumorigenic Endothelial Cells (EOMA) cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells, making it a potential target for EOMA therapeutics.

  4. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  5. Lentivirus-based RNAi stably knocks down the expression of the Mrp1 gene in the established TM4 (show TPM4 Proteins) sertoli cell line.

  6. neprilysin (show MME Proteins) x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes

  7. Expression of apoA-I (show APOA1 Proteins) or ABCA1 (show ABCA1 Proteins) can reduce steatosis by decreasing lipid storage in hepatocytes through lipid transport and may also reduce endoplasmic reticulum stress, further lessening hepatic steatosis

  8. Loss of Mrp1 coupled with reductions in steroid hormone levels leads to alterations in extrahepatic phase I, phase II and phase III metabolizing enzymes in a tissue-specific manner.

  9. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2 (show ABCC2 Proteins), in WT cells but not in metallothionein (show MT Proteins)-null cells.

  10. These results identify Mrp1 as the transporter essential for S1P (show S1PR1 Proteins) efflux from the endothelial cells and thus for inside-out S1P (show S1PR1 Proteins) signaling to P-glycoprotein at the blood-brain and blood-spinal cord barriers.

Cow (Bovine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. Using electron cryomicroscopy, authors determined the molecular structures of bovine MRP1 in two conformations: an apo (show C9orf3 Proteins) form at 3.5 A without any added substrate and a complex form at 3.3 A with one of its physiological substrates, leukotriene C4; structures show that by forming a single bipartite binding site, MRP1 can recognize a of substrates with different chemical structures.

  2. P-gp (show ABCB4 Proteins), Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

ABCC1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.

Gene names and symbols associated with ABCC1

  • ATP binding cassette subfamily C member 1 (ABCC1)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1)
  • ATP binding cassette subfamily C member 1 (Abcc1)
  • ABC29 protein
  • ABCC protein
  • Abcc1a protein
  • Abcc1b protein
  • Avcc1a protein
  • GS-X protein
  • Mdrap protein
  • Mrp protein
  • Mrp1 protein

Protein level used designations for ABCC1

ATP-binding cassette transporter variant ABCC1delta-ex13 , ATP-binding cassette transporter variant ABCC1delta-ex13&14 , ATP-binding cassette transporter variant ABCC1delta-ex25 , ATP-binding cassette transporter variant ABCC1delta-ex25&26 , LTC4 transporter , leukotriene C(4) transporter , multidrug resistance-associated protein 1 , ATP-binding cassette sub-family C member 1 , multidrug resistance protein 1 , ATP-binding cassette, sub-family C (CFTR/MRP), member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1b , multiple drug resistance-associated protein , ATP-binding cassette sub-family C ( CFTR/MRP) member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1 , ATP-binding cassette superfamily member C1 , ATP-binding cassette transporter sub-family C member 1 , ATP-binding cassette, sub-family C, member 1 , multiple drug resistance protein 1

GENE ID SPECIES
4363 Homo sapiens
281588 Bos taurus
395416 Gallus gallus
403453 Canis lupus familiaris
17250 Mus musculus
24565 Rattus norvegicus
100734674 Cavia porcellus
733619 Sus scrofa
791240 Equus caballus
100345841 Oryctolagus cuniculus
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