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ACVRL1 encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands.
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Results show that ALK5 (show TGFBR1 ELISA Kits) and ALK1 play antagonistic roles in TGF-beta (show TGFB1 ELISA Kits)-induced podosome formation in aortic endothelial cells.
ALK1 and ALK5 (show TGFBR1 ELISA Kits) are both essential for correct regulation of VEGF (show VEGFA ELISA Kits), and that disruption of either pathway leads to disease.
alk1 loss has no effect on arterial endothelial cell proliferation but alters arterial endothelial cell migration within lumenized vessels.
Control of Notch (show NOTCH1 ELISA Kits) targets in arterial endothelium is context-dependent, with gene-specific and region-specific requirements for Notch (show NOTCH1 ELISA Kits) and Alk1
Blood flow is required not only for alk1 expression but also for Alk1 activity.
Study demonstrate that alk1 expression requires blood flow, and despite normal levels of shear stress, some flow-responsive genes are dysregulated in alk1 mutant arterial endothelial cells.
vbg encodes activin receptor-like kinase 1 (acvrl1), a TGFbeta (show TGFB1 ELISA Kits) type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants.
The present study showed that deletion-duplication mutations in the BMPR2 (show BMPR2 ELISA Kits) or ACVRL1 genes may not be associated with non-regression of Pulmonary arterial hypertension.
Study identified 2 non-synonymous missense mutations: c.C652T, p.R218W in ACVRL1, c.C717G, p.D239E in SGCD (show SGCD ELISA Kits) in Chinese population with total anomalous pulmonary venous return.
Mutations in ACVRL1 gene encoding for transforming growth factor (TGF)-[beta] superfamily have been identified in Pulmonary Arterial Hypertension.
Treatment-related telangiectasia was noted in 7% of patients, suggesting in vivo inhibition of the ALK-1 pathway.
Data indicate that simultaneous targeting of molecules that control distinct phases of angiogenesis, such as ALK1 and VEGFR, is a valid strategy for treatment of metastatic renal cell carcinoma (mRCC).
Study showed that rs706819, rs2293094, and rs11169953 polymorphisms in the ACVRL1 gene are associated with higher susceptibility to brain arteriovenous malformations.
c.1027C > T(p.Gln343) mutation within the ACVRL1 gene in family with hereditary hemorrhagic telangiectasia
Bone morphogenetic protein (BMP)9 (show GDF2 ELISA Kits) and BMP10 (show BMP10 ELISA Kits) are high affinity ligands for activin receptor-like kinase 1 (ALK1).
Activin receptor-like kinase (ALK)1 is a transforming growth factor beta (TGF-beta) type I receptor (show TGFBR1 ELISA Kits) predominantly expressed in actively proliferating endothelial cells (ECs).
Two novel missense mutations and two recurrent mutations in the ACVRL1 gene are associated with pulmonary arterial hypertension in in Chinese families.
Data show that concomitant activin receptor-like kinase 1 (Acvrl1) and endoglin (Eng (show ENG ELISA Kits)) deficiency synergistically decreases pancreatic neuroendocrine tumor volume.
Global deletion of AlK-1 is associated with the development of high output heart failure without maladaptive remodeling.
These data indicate that both Itgb8 and Alk1 are important in maintaining normal cerebral angiogenesis in response to VEGF (show VEGFA ELISA Kits). Itgb8 deficiency enhances the formation of dysplastic vessels and hemorrhage in Alk1 (+/-) mice.
these studies characterize an accessory TGF-beta (show TGFB1 ELISA Kits)-stimulated BMP R-Smad (show SMAD1 ELISA Kits) signaling mechanism in interstitial cells of the developing lung.
this study demonstrates that ACVRL1 signaling plays a pivotal role whereby it suppresses plasmacytoid dendritic cell development while enhancing that of CD8alpha(+) dendritic cells, thus contributing to DC diversity development.
CD109 (show CD109 ELISA Kits) differentially regulates TGF-beta (show TGFB1 ELISA Kits)-induced ALK1-Smad1 (show SMAD1 ELISA Kits)/5 versus ALK5 (show TGFBR1 ELISA Kits)-Smad2 (show SMAD2 ELISA Kits)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 (show CD109 ELISA Kits) expression regulates dermal function through a paracrine mechanism
he results of the present study demonstrated that BMP9 (show GDF2 ELISA Kits) promoted the osteoclast differentiation of osteoclast precursors via binding to the ALK1 receptor on the cell surface, and inhibiting the ERK1/2 (show MAPK1/3 ELISA Kits) signaling pathways in the cell
Conclude that the ALK-1 receptor is involved in the control of arterial pressure. High AP of Alk1(+/-) mice is explained mainly by the sympathetic overactivation, which is probably related to the decreased number of cholinergic neurons.
Report interaction between ALK1 signaling and connexin40 in the development of arteriovenous malformations.
In vascular sprouting, neuropilin-1 (show NRP1 ELISA Kits) suppresses the stalk-cell phenotype by limiting Smad2 (show SMAD2 ELISA Kits)/3 activation through Alk1 and Alk5 (show TGFBR1 ELISA Kits). Notch (show NOTCH1 ELISA Kits) downregulates Nrp1 (show NRP1 ELISA Kits), thus relieving the inhibition of Alk1 and Alk5 (show TGFBR1 ELISA Kits), thereby driving stalk-cell behaviour.
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
activin A receptor type II-like 1
, serine/threonine-protein kinase receptor R3
, serine/threonine-protein kinase receptor R3-like
, activin receptor-like kinase 1
, violet beauregarde
, TGF-B superfamily receptor type I
, activin A receptor, type II-like kinase 1
, Activin receptor like kinase 1
, activin receptor-like kinase-1