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Plays a role in the endosomal sorting pathway (By similarity). Additionally we are shipping CHMP7 Proteins (6) and and many more products for this protein.
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Human Polyclonal CHMP7 Primary Antibody for ICC, IF - ABIN4298022
Kim, Kim, Park, Cho, Goughnour, Han, Yoon, Kim, Kang, Song, Kim, Choi, Mun, Song, Lee, Jung, Kim: Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells. in The Journal of cell biology 2017
We conclude that Lem2p/LEM2 is a conserved nuclear site-specific adaptor that recruits Cmp7p/CHMP7 and downstream ESCRT factors to the nuclear envelope.
The N terminus of CHMP7 acts as a novel membrane-binding module. This membrane-binding ability allows CHMP7 to bind to the endoplasmic reticulum, an organelle continuous with the nuclear envelope (NE), and it provides a platform to direct NE recruitment of ESCRT-III during mitotic exit.
Results suggest that CHMP7, a novel CHMP4-associated ESCRT-III-related protein, functions in the endosomal sorting pathway.
UBPY MIT domain and another ubiquitin isopeptidase, AMSH, reveals common interactions with CHMP1A and CHMP1B but a distinct selectivity of AMSH for CHMP3/VPS24, a core subunit of the ESCRT-III complex, and UBPY for CHMP7.
Plays a role in the endosomal sorting pathway (By similarity).
CHMP family, member 7
, chromatin-modifying protein 7