Calcium Homeostasis Modulator 1 Proteins (CALHM1)

CALHM1 encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. Additionally we are shipping CALHM1 Antibodies (46) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CALHM1 255022 Q8IU99
Rat CALHM1 CALHM1 499367  
CALHM1 546729  
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Top CALHM1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details

CALHM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Calcium Homeostasis Modulator 1 (CALHM1) Interaction Partners

Human Calcium Homeostasis Modulator 1 (CALHM1) interaction partners

  1. Meta-analysis suggested that CALHM1 rs2986017 might be associated with increased Alzheimer's disease risk in Caucasian, but not Asian population

  2. In the presence of antibody, P86L-CALHM1 shifts the balance between neurodegeneration and neuronal survival toward the stimulation of pro-cytotoxic pathways, thus potentially contributing to its deleterious effects in Alzheimer's disease.

  3. CALHM1 polymorphism may be potential biomarker in patients with Alzheimer disease. [meta-analysis]

  4. The rare R154H variant interferes with CALHM1 control of cytosolic Ca2+ and Abeta accumulation.

  5. CALHM1 p.P86L variation may not be an AD susceptibility factor in the Han Chinese population.

  6. This study showed that No association between polymorphisms in the calcium homeostasis modulator 1 gene and mesial temporal lobe epilepsy risk in a Chinese population

  7. rare genetic variants in CALHM1 lead to Ca(2+) dysregulation and may contribute to the risk of EOAD through a mechanism independent from the classical Ass cascade.

  8. The study identifies a previously uncharacterized mechanism of control of Ca(2+)-dependent ERK1/2 signaling in neurons, and further establishes CALHM1 as a critical ion channel for neuronal signaling and function.

  9. Our data show that CLHM-1 is a functionally conserved ion channel that plays an important but potentially toxic role in excitable cell function.

  10. Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins.

  11. CALHM1 is a voltage-gated ATP-release channel required for sweet, bitter and umami taste perception

  12. A TGG haplotype defined by the rs4918016-rs2986017-rs2986018 block was associated with sporadic Creutzfeldt-Jakob disease.

  13. An association between the CALHM1 polymorphism and the risk for Alzheimer's disease, was not detected.

  14. Data show a significant association of CALHM1 P86L with elevated CSF Abeta42 and Abeta40 in the normal cohort at risk for Alzheimer's disease.

  15. CALHM1 increases Ca(2+) leak from the ER and, more importantly, reduces the endoplasmic reticulum Ca(2+) uptake by decreasing both the transport capacity and the Ca(2+) affinity of SERCA.

  16. These results indicate that the CALHM1 Pro86Leu polymorphism may modulate age of onset of Alzheimer's disease by interacting with the effect of the epsilon4 allele of apolipoprotein E.

  17. The results of this study provide the first evidence that the SNP rs11191692 in CALHM1 confers highly increased susceptibility to temporal lobe epilepsy.

  18. This study demonistrated that CALHM1 allele (13.5% vs 16.7%) and genotype frequency was not significantly different between Alzheimer's disease (AD) and controls.

  19. the CALHM1 P86L common variant may not influence Alzheimer disease risk in Japanese

  20. This study for the first time finds that the GOLPH2 modifies the ApoE[varepsilon]4-associated risk of Alzheimer's disease.

CALHM1 Protein Profile

Protein Summary

This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.

Gene names and symbols associated with CALHM1

  • calcium homeostasis modulator 1 (CALHM1)
  • novel protein similar to vertebrate calcium homeostasis modulator protein family (LOC557535)
  • calcium homeostasis modulator 1 (Calhm1)
  • EG546729 protein
  • Fam26c protein
  • RGD1564891 protein

Protein level used designations for CALHM1

calcium homeostasis modulator 1 , novel protein similar to vertebrate calcium homeostasis modulator protein family , calcium homeostasis modulator protein 1 , family with sequence similarity 26, member C

GENE ID SPECIES
466194 Pan troglodytes
486871 Canis lupus familiaris
532026 Bos taurus
557535 Danio rerio
100349950 Oryctolagus cuniculus
100069751 Equus caballus
100601788 Nomascus leucogenys
255022 Homo sapiens
499367 Rattus norvegicus
546729 Mus musculus
428977 Gallus gallus
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