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CALHM1 encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein.
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Meta-analysis suggested that CALHM1 rs2986017 might be associated with increased Alzheimer's disease risk in Caucasian, but not Asian population
In the presence of antibody, P86L-CALHM1 shifts the balance between neurodegeneration and neuronal survival toward the stimulation of pro-cytotoxic pathways, thus potentially contributing to its deleterious effects in Alzheimer's disease.
CALHM1 polymorphism may be potential biomarker in patients with Alzheimer disease. [meta-analysis]
The rare R154H variant interferes with CALHM1 control of cytosolic Ca2 (show CA2 Proteins)+ and Abeta (show APP Proteins) accumulation.
CALHM1 p.P86L variation may not be an AD susceptibility factor in the Han Chinese population.
This study showed that No association between polymorphisms in the calcium homeostasis modulator 1 gene and mesial temporal lobe epilepsy risk in a Chinese population
rare genetic variants in CALHM1 lead to Ca(2 (show CA2 Proteins)+) dysregulation and may contribute to the risk of EOAD through a mechanism independent from the classical Ass (show ASS1 Proteins) cascade.
The study identifies a previously uncharacterized mechanism of control of Ca(2 (show CA2 Proteins)+)-dependent ERK1/2 signaling in neurons, and further establishes CALHM1 as a critical ion channel for neuronal signaling and function.
Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins.
CALHM1 is a voltage-gated ATP-release channel required for sweet, bitter and umami taste perception
CALHM1 gating and association with lipid microdomains are post-translationally regulated through the process of protein S-palmitoylation.
Calhm1 deletion changes activation kinetics of large voltage-gated outward currents and their associated nonselective tail currents in taste bud cells. Calhm1 deletion reduced the half-widths of action potentials and accelerated the deactivation kinetics of transient outward currents in taste bud cells.
Thus, CALHM1 controls synaptic activity in cerebral neurons and is required for the flexible processing of memory in mice.
Abeta (show APP Proteins) level reduction by CALHM1 could be explained by an increase in extracellular Abeta (show APP Proteins) degradation by insulin-degrading enzyme (show IDE Proteins).
Multiple transduction pathways make complex, concentration-dependent contributions to salty taste perception. One of these pathways depends on CALHM1 to detect hypertonic NaCl in the mouth and signal the aversive taste of concentrated salt.
This study demonistrated that the Calhm1 knockot mice consumed only half as much sugar per day as did Wild type mice.
Calhm1 was of rare abundance in brain tissues
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.
calcium homeostasis modulator 1
, novel protein similar to vertebrate calcium homeostasis modulator protein family
, calcium homeostasis modulator protein 1
, family with sequence similarity 26, member C