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Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Additionally we are shipping Calpain 9 Antibodies (42) and many more products for this protein.
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calpain-9 may play a role in breast cancer and that low expression is associated with poorer patient clinical outcome following endocrine therapy.
We have solved the structures of human calpain 1 (show CAPN1 Proteins) and calpain 9 protease cores ; both structures have clear implications for the function of non-catalytic domains of full-length calpains in the calcium-mediated activation of the enzyme.
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, digestive tract-specific calpain
, new calpain 4
, novel calpain large subunit-4