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C6orf25 is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. Additionally we are shipping C6orf25 Antibodies (32) and many more products for this protein.
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G6B seems to act through an autosomal recessive mode of disease transmission in this family and regarded as the gene responsible for the observed hematological disorder.
Heparin might modulate the interaction of G6b with its as yet unidentified protein ligand
G6B represents a novel inhibitory receptor found on the surface of platelets
G6b-B expression is highly restricted to peripheral CD4 (show CD4 Proteins)+ T cells and up-regulated by the IL-4 (show IL4 Proteins)-induced STAT6 (show STAT6 Proteins) pathway, suggesting that G6b-B is involved in regulation of the immune response by CD4 (show CD4 Proteins)+ T cell-mediated and IL-4 (show IL4 Proteins) induced regulatory mechanisms.
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2 (show CLEC1B Proteins).
these findings establish G6b-B as a major inhibitory receptor regulating megakaryocyte activation, function, and platelet production.
This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene.
, immunoglobulin receptor
, G6B protein
, G6b protein
, ITIM-receptor G6b-B