The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009].
Gegunde, Alfonso, Alvariño, Alonso, Botana: "Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions." in: Frontiers in immunology, Vol. 12, pp. 609196, (2021) (PubMed).
Ray, Sullenger, White: "Further characterization of the target of a potential aptamer biomarker for pancreatic cancer: cyclophilin B and its posttranslational modifications." in: Nucleic acid therapeutics, Vol. 23, Issue 6, pp. 435-42, (2013) (PubMed).
Aliases for PPIB Proteins
peptidylprolyl isomerase B (ppib) Proteins peptidylprolyl isomerase B (PPIB) Proteins peptidylprolyl isomerase B (Ppib) Proteins peptidylprolyl isomerase B (CC1G_03223) Proteins peptidylprolyl isomerase B (cyclophilin B) (Ppib) Proteins peptidylprolyl isomerase B L homeolog (ppib.L) Proteins peptidylprolyl isomerase B (cyclophilin B) (PPIB) Proteins peptidylprolyl isomerase B (cyclophilin B) (ppib) Proteins AA408962 Proteins AA553318 Proteins ACYPI004891 Proteins AI844835 Proteins cb87 Proteins Cphn-2 Proteins Cphn2 Proteins CyP-20b Proteins cyp-s1 Proteins CYP-S1 Proteins cypb Proteins CypB Proteins CYPB Proteins OI9 Proteins PPIB Proteins Ppib Proteins sb:cb87 Proteins scylp Proteins Scylp Proteins SCYLP Proteins wu:fa97f08 Proteins zgc:73214 Proteins zgc:86796 Proteins