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DAOA encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Additionally we are shipping D-Amino Acid Oxidase Activator Kits (9) and D-Amino Acid Oxidase Activator Proteins (3) and many more products for this protein.
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G72 transgenic mice have larger excitatory synapses with an increased amount of N-methyl-d-aspartate (NMDA) receptors in the molecular layer of dentate gyrus, compared with wild-type littermates. Transgenic animals have lower number of dentate granule cells with a parallel, but an even stronger decrease in the number of excitatory synapses in the molecular layer.
pLG72 interacts with neosynthesized d-amino acid oxidase (show DAO Antibodies) (hDAAO), promoting its inactivation and degradation. In this work, we used low-resolution techniques to characterize the surface topology of the hDAAO-pLG72 complex.
Data show that the R30K D-amino acid oxidase activator pLG72 is significantly more prone to degradation than the R30 and the K62E variants in a cell system.
Studies successfully predicted the structures of the N- and C-terminal domains (ND and CD, respectively) of G72.
We suggest that serum G72 protein levels may represent a candidate biomarker for schizophrenia and have confirmed the results of the previous preliminary study.
A Mutation in DAOA Modifies the Age of Onset in PSEN1 (show PSEN1 Antibodies) E280A Alzheimer's Disease. Findings strongly suggest that this new conspicuous functional age of onset modifier within the G72 (DAOA) gene could be pivotal for understanding the genetic basis of Alzheimer's disease.
DAOA gene may contribute to the risk for Psychotic disorders and that this gene may play a role as a modulator of executive function.
pLG72 level being significantly increased in the serum of patients with schizophrenia, have led us to propose that the ROS (show ROS1 Antibodies) enhancement in mental diseases may be from the overexpression of pLG72 in brain cells.
Report in silico analysis of DAOA for the design of inhibitors for treatment of schizophrenia.
This study suggested that structural lipid alterations in oligodendrocyte glycosynapses are responsible for dysconnectivity in schizophrenia and that increased expression of G72 protein may play a role in the development of abnormal glycosynapses.
tadpoles contained high concentrations of D-proline close to the final developmental stage and nearly no D-amino acids were detected in the adult frog, indicating that D-amino acid oxidase (show DAO Antibodies) functions in metamorphosis.
This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
, schizophrenia- and bipolar disorder-associated protein G72
, D-amino-acid oxidase
, D-amino acid oxidase
, D-amino-acid oxidase-like