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DGAT2 encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. Additionally we are shipping DGAT2 Antibodies (89) and DGAT2 Proteins (7) and many more products for this protein.
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Study identified a large cohort of patients with congenital diarrheal disorders with mutations in DGAT1 (show DGAT1 ELISA Kits) that reduced expression of its product; dermal fibroblasts and intestinal organoids derived from these patients had altered lipid metabolism and were susceptible to lipid-induced cell death. Expression of full-length wildtype DGAT1 (show DGAT1 ELISA Kits) or DGAT2 restored normal lipid metabolism in these cells.
We first report loss-of-function mutations in DGAT2 and FAAH (show FAAH ELISA Kits) in one obese subject, which may interact with each other to affect the adiposity penetrance, providing a model of genetic interaction associated with human obesity.
The findings indicate the functionality of the prostate cancer death-predisposing SNPs rs143975731, rs12277366, rs2155225, and rs2155222 as DGAT2 regulators in prostate tumors.
Diacylglycerol acyltransferase-2 (show AWAT1 ELISA Kits) and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome (show Psmd4 ELISA Kits)
Results identified a novel de novo p.Y223H mutation in the DGAT2 from an autosomal-dominant Korean Charcot-Marie-Tooth (CMT) family suggesting this mutation a novel underlying cause of an autosomal-dominant CMT2 phenotype.
uPA (show PRAP1 ELISA Kits)/uPAR (show PLAUR ELISA Kits) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38 (show CRK ELISA Kits)-dependent upregulation of DGAT2
DGAT2 is regulated by gp78 (show AMFR ELISA Kits)-associated endoplasmic-reticulum-associated degradation at the post-translational level.
Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia.
describe distinct but synergistic roles of the two DGATs in an integrated pathway of TAG synthesis and secretion, with DGAT2 acting upstream of DGAT1 (show DGAT1 ELISA Kits)
Niacin treatment may reduce liver fat content in Chinese patients with dyslipidemia and the mechanism may involve inhibition of DGAT2.
Data showed the associations between SNPs in intron 6 and intron 7 of the bovine diacylglycerolacyltransferase (show DGAT1 ELISA Kits) (DGAT2) gene and growth traits in purebred Nanyang cattle.
Study on the polymorphisms of DGAT2 gene in 92 Jiaxian red cattle show that genotype AB may have positive effect on body weight.
These results suggest that the 13bp indel polymorphism in the 3'-UTR (show UTS2R ELISA Kits) of porcine DGAT2 most likely affects fat deposition by altering its expression in pigs.
The porcine CTNNBL1 (show CTNNBL1 ELISA Kits) and DGAT2 genes affect porcine fat deposition and further investigation will be necessary to illustrate the underlying mechanisms.
DGAT1 (show DGAT1 ELISA Kits) does not contribute to this pathway, but uses exogenous FA and glycerol to synthesize a functionally distinct pool of TAG to which DGAT2 also contributes...in b3-agonist activated brown adipocytes, DGAT2 specifically enables channelling of de novo synthesized FA into a rapidly mobilized pool of TAG, which is simultaneously hydrolyzed to provide substrates for mitochondrial fatty acid oxidation.
these results support a model where Dgat1 (show DGAT1 ELISA Kits) and Dgat2 function coordinately to regulate the process of dietary fat absorption by preferentially synthesizing TAG for incorporation into distinct subcellular TAG pools in enterocytes.
when intestinal DGAT2 is present in excess, mRNA levels of genes involved in fatty acid oxidation were reduced. This result suggests that reduced fatty acid oxidation may contribute to increased TG secretion by overexpression of DGAT2 in intestine
role of Mtp and DGAT2 in hepatic steatosis
DGAT2 is capable of catalyzing TG synthesis and promote its storage in cytosolic lipid droplets independent of its localization in the ER.
DAG-induced PKCepsilon (show PRKCE ELISA Kits) activation plays a major role in nonalcoholic fatty liver disease (NAFLD (show TSC2 ELISA Kits))-associated hepatic insulin (show INS ELISA Kits) resistance.
Findings show that DGAT1 and DGAT2 account for the vast majority of TG synthesis in mice, and DGAT function is required for LDs in adipocytes, but not in all cell types.
upregulation of DGAT2 plays an important role in the pathogenesis of alcoholic fatty liver disease
the increased rate of hepatic TAG secretion and intracellular accumulation in ob/ob mice is accompanied by parallel increases in the activities of both DGAT I and DGAT II
DGAT2 expression is increased in diabetic mice.
expression of a codon-optimized version of the DGAT2 gene is able to restore neutral lipid accumulation in the Saccharomyces cerevisiae mutant strain
Using immunogold technique, DGAT2 found in lipid bodies associated with microtubules; microtubules may participate in lipid biosynthesis as indicated by the presence of DGAT2. [DGAT2]
This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene.
acyl-CoA retinol O-fatty-acyltransferase
, diacylglycerol O-acyltransferase homolog 2
, diacylglycerol O-acyltransferase-like protein 2
, diglyceride acyltransferase 2
, retinol O-fatty-acyltransferase
, putative diacylglycerol O-acyltransferase
, diacylglycerol acytransferase 2
, diacylglycerol acyltransferase 2
, diacylglycerol O-acyltransferase 2