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Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. Additionally we are shipping DUOXA1 Antibodies (11) and many more products for this protein.
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We analyzed the expression of NADPH oxidase (show NOX1 Proteins) isoforms and found both A431 and HaCaT cells to express the calcium-sensitive NADPH oxidase (show NOX1 Proteins), Dual oxidase 1 (Duox1 (show DUOX1 Proteins)) and its protein partner Duox (show DUOX1 Proteins) activator 1 (DuoxA1).Our observations provide evidence for a new signaling paradigm in which changes of intracellular calcium concentration are transformed into redox signals through the calcium-dependent activation of Duox1 (show DUOX1 Proteins).
DUOXA1 transient overexpression affected the cell-cell adhesion by modulating the actin cytoskeleton
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
DUOXA1 overexpression in muscle stem cells induces apoptosis and inhibits differentiation through DUOX1 (show DUOX1 Proteins) and ASK1 (show MAP3K5 Proteins).
DUOXA1 is a novel p53 (show TP53 Proteins)-regulated neurogenic factor involved in p53 (show TP53 Proteins) dependent neuronal differentiation.
Nip1 has an important role in the guidance of neuronal differentiation through ROS (show ROS1 Proteins) generation and modulation of intermediate filaments
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
dual oxidase maturation factor 1
, Numb-interacting protein
, dual oxidase activator 1
, dual oxidase maturation factor 1 alpha
, dual oxidase maturation factor 1 beta
, dual oxidase maturation factor 1 delta
, dual oxidase maturation factor 1 gamma
, homolog of Drosophila Numb-interacting protein
, Numb-interacting protein 1