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Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.. Additionally we are shipping Elongation Factor RNA Polymerase II Antibodies (94) and Elongation Factor RNA Polymerase II Kits (2) and many more products for this protein.
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ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 (show THBS1 Proteins) regulation
The results indicate that p53 interferes with the interaction between ELL/EAF and ICE1 and represses transcription of small nuclear RNA genes by Pol II.
This work reveals a previously unrecognized function for ELL as an E3 ubiquitin ligase (show MUL1 Proteins) for c-Myc (show MYC Proteins) and a potential tumour suppressor.
The Tax (show CNTN2 Proteins) oncogene (show RAB1A Proteins) enhances ELL incorporation into p300 (show EP300 Proteins) and P-TEFb (show CCNT1 Proteins) containing protein complexes to activate transcription.
eleven-nineteen lysine-rich leukemia protein enhanced E2F1 (show E2F1 Proteins) deacetylation via recruitment of histone deacetylase 1 (show HDAC1 Proteins)
ELL is an essential player for RNA Pol II restart during cellular DNA damage response.
Studies indicate that the super elongation complex (SEC) consisting of ELL, P-TEFb (CDK9) and MLL required for rapid transcriptional induction in the presence or absence of paused RNA polymerase II (Pol II).
ELL has an early and essential role during rapid high-amplitude gene expression that is required for both Pol II pause site entry and release
Our findings suggest that ELL and HIF-1alpha (show HIF1A Proteins) are binding partners and can modulate the functions of each other in hypoxia.
In the Acute Myeloid Leukemia (show BCL11A Proteins) patients, detected MLL (show MLL Proteins) rearrangements consisting of MLL (show MLL Proteins)/AF6, MLL (show MLL Proteins)/AF9 (show MLLT3 Proteins), MLL (show MLL Proteins)/AF17 , MLL (show MLL Proteins)/ELL and MLL (show MLL Proteins) partial tandem duplication. MLL (show MLL Proteins) rearrangement include chromosome translocation and partial tandem duplication.
Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
RNA polymerase II elongation factor ELL
, ELL gene (11-19 lysine-rich leukemia gene)
, eleven-nineteen lysine-rich leukemia protein
, protein phosphatase 1, regulatory subunit 68
, RNA POLYMERASE II ELONGATION FACTOR ELL (ELEVEN-NINETEEN LYSINE-RICH LEUKEMIA PROTEIN)