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ENGASE encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. Additionally we are shipping ENGASE Antibodies (16) and ENGASE Kits (6) and many more products for this protein.
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In patients with autosomal dominant polycystic kidney disease, urinary NAGase was correlated with urinary ET-1 (show EDN1 Proteins) which was inversely associated with eGFR (show EGFR Proteins) and positively correlated with total kidney volume.
Serological N-acetyl-glucosaminidase (show NAGLU Proteins), telomere length, and the UCP2 (show UCP2 Proteins)-886G>A variant are independent risk factors for type 2 diabetes.
As the generation of the bulk of fOS is unaffected by co-down regulation of Ngly1p and Engase1p, alternative quantitatively important mechanisms must underlie the liberation of these fOS from either LLO or glycoproteins during protein N-glycosylation.
O-GlcNAcase (show MGEA5 Proteins) expression is increased in erythrocytes from both individuals with pre-diabetes and individuals with less well-controlled diabetes.
involved in processing of free oligosaccharides in the cytosol; identification of the gene encoding human cytosolic ENGase
endo-beta-n-acetylglucosaminidase present in the synovial fluid of rheumatoid arthritis patients, may contribute to the depletion of glycosaminoglycans from cartilage allowing the invasion of synovial cells
identification of O-GlcNAcase (show MGEA5 Proteins) as a caspase-3 (show CASP3 Proteins) substrate with a novel caspase-3 (show CASP3 Proteins) cleavage site and provide insight about O-GlcNAcase (show MGEA5 Proteins) regulation during apoptosis.
These observations strongly suggest that the Ngly1 (show NGLY1 Proteins)- or Ngly1 (show NGLY1 Proteins)/Engase-deficient mice could serve as a valuable animal model for studies related to the pathogenesis of the NGLY1 (show NGLY1 Proteins)-deficiency, and that cytoplasmic ENGase represents one of the potential therapeutic targets for this genetic disorder.
ENGase efficiently hydrolyzes phosphorylated oligosaccharides that are larger than Man4GlcNAc2-P, generating GlcNAc-1-P and neutral Gn1 (show GYG1 Proteins)-type free oligosaccharides.
This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides.
, Di-N-acetylchitobiosyl beta-N-acetylglucosaminidase
, Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
, Cytosolic endo-beta-N-acetylglucosaminidase