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The protein encoded by EHMT1 is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. Additionally we are shipping EHMT1 Antibodies (135) and EHMT1 Kits (2) and many more products for this protein.
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GLP/G9a (show EHMT2 Proteins) H3K9 methyltransferase complex is an enzyme counteracting Jmjd1a (show KDM3A Proteins)-mediated H3K9 demethylation at the Sry (show SRY Proteins) locus in gonadal somatic cells
miR (show MLXIP Proteins)-217-mediated, genetic, or pharmacological inactivation of EHMT1/2 was sufficient to promote pathological hypertrophy
EHMT1 Mediates Homeostatic Synaptic Scaling
The stress-induced Brg1 (show SMARCA4 Proteins)-G9a (show EHMT2 Proteins)/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Proteins) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
data provide genetic and pharmacologic evidence that EHMT1 and EHMT2 (show EHMT2 Proteins) are epigenetic regulators involved in gamma-globin repression and represent a novel therapeutic target for SCD (show SCD Proteins).
histone methyltransferase activities of GLP and G9a (show EHMT2 Proteins) are stimulated by neighboring nucleosomes that are premethylated at H3K9
Prdm16 (show PRDM16 Proteins) was required in young mice to suppress the expression of white-fat-selective genes in BAT (show BAAT Proteins) through recruitment of the histone methyltransferase Ehmt1.
G9a and GLP have an essential role in normal morphogenesis of the atrioventricular septum through regulation of the size of the atrioventricular cushion.
Reduced Euchromatin histone methyltransferase 1 (show DNMT1 Proteins) causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice.
EHMT1 is an essential BAT (show BAAT Proteins)-enriched lysine methyltransferase in the PRDM16 (show PRDM16 Proteins) transcriptional complex and controls brown adipose cell fate
trr (show TXNRD1 Proteins) and G9a (show EHMT2 Proteins) also have common direct targets, including the Drosophila ortholog of Arc (show NOL3 Proteins) (Arc1 (show CDH1 Proteins)), a key regulator of synaptic plasticity. Our data highlight the clinical and molecular convergence between the KMT2 and EHMT protein families, which may contribute to a molecular network underlying a larger group of intellectual disability / autism spectrum disorder -related disorders.
missense variants in EHMT1 that lead to protein misfolding and disrupted histone mark binding can lead to Kleefstra Syndrome [case reports]
we find an estrogen receptor-independent synthetic lethal interaction between a GATA3 frameshift mutant with an extended C-terminus and the histone methyltransferases G9A and GLP, indicating perturbed epigenetic regulation
Selective degradation of the mutant EHMT1 mRNA leads to Kleefstra syndrome.
G9a (show EHMT2 Proteins) and GLP (show RCBTB1 Proteins) are required for stable maintenance of imprinted DNA methylation (show HELLS Proteins) in embryonic stem cells.
the clinical picture we found in Norwegian patients with Kleefstra syndrome is similar to the findings described in the literature. An interesting point is that in the literature >85% of the patients have a deletion of 9q34.3 and the remaining have a mutation in the EHMT1 gene, whereas in this study we found 50% with a deletion, and 50% with a mutation.
Data indicate zinc finger proteins ZNF644 and WIZ as two core subunits in the histone-lysine N-methyltransferase G9a/GLP complex, and interact with the transcription activation domain of G9a and GLP.
data provide genetic and pharmacologic evidence that EHMT1 and EHMT2 (show EHMT2 Proteins) are epigenetic regulators involved in gamma-globin (show HBG1 Proteins) repression and represent a novel therapeutic target for SCD (show SCD Proteins).
The expression level of EHMT1 and EHMT2 (show EHMT2 Proteins) inversely correlates with the type I interferon (show IFNA Proteins) responsiveness in chronic myeloid leukemia (show BCL11A Proteins) cell lines.
The current knowledge on the mechanisms of action and function of EHMT1, with particular emphasis on their interplay in the regulation of chromatin states and biological processes.
The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome). Two transcript variants encoding different isoforms have been found for this gene.
euchromatic histone methyltransferase 1
, histone-lysine N-methyltransferase, H3 lysine-9 specific 5
, euchromatic histone-lysine N-methyltransferase 1
, histone-lysine N-methyltransferase EHMT1
, histone-lysine N-methyltransferase, H3 lysine-9 specific 5-like
, G9a-like protein 1
, lysine N-methyltransferase 1D
, G9a like protein
, H3-K9-HMTase 5
, histone H3-K9 methyltransferase 5