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FBXL2 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXL2 Antibodies (52) and FBXL2 Kits (12) and many more products for this protein.
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PTEN counteracts FBXL2 to promote IP3R3 (show ITPR3 Proteins)- and Ca(2 (show CA2 Proteins)+)-mediated apoptosis limiting tumour growth
these results uncover a previous unknown network involving FBXL2 and FoxM1 (show FOXM1 Proteins) in the regulation of gastric cancer growth.
FBXL2 recognizes Trp-73 within NALP3 for interaction and targets Lys-689 within NALP3 for ubiquitin ligation and degradation.
FBXL2 mediates the ubiquitylation and degradation of p85beta on cell membranes.
These results suggested that the involvement of the reduction of FBL2 level is related to AD progression.
FBXL2 is indispensible regulator of mitosis that serves as a tumor suppressor
FBXL2 targets cyclin D2 (show CCND2 Proteins) for ubiquitination and degradation to inhibit leukemic cell proliferation.
FBL2 is a novel and dual regulator of amyloid precursor protein (APP (show APP Proteins)) metabolism through FBL2-dependent ubiquitination of APP (show APP Proteins).
Study demonstrated that TRAF6 (show TRAF6 Proteins) plays an important role in the process of aseptic inflammatory loosening caused by periprosthetic debris, and Low intensity pulsed ultrasound was found to inhibit such inflammation through increasing the level of FBXL2, and further increasing ubiquitination of TRAF6 (show TRAF6 Proteins).
FBXL2 mediates Aurora B (show AURKC Proteins) ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis.
FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
F-box protein FBL2/FBL3
, F-box protein containing leucine-rich repeats
, F-box/LRR-repeat protein 2
, F-box and leucine-rich repeat protein 20