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The protein encoded by FPA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Additionally we are shipping Fibrinopeptide A Kits (35) and and many more products for this protein.
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The risk of early pregnancy loss was significantly higher in women with homozygous or heterozygous FGA (show FGA Antibodies): p.Thr331Ala polymorphism than in women with FGA (show FGA Antibodies): p.Thr331 (Odds ratio: 8.84, P < .05).
Data defined the mutational burden of the fibrinogen FGA, FGB, and FGG genes, and estimated the prevalence of inherited fibrinogen disorders through a systematic analysis of exome/genome data.
CD47 (show CD47 Antibodies) expression is decreased on the surface of erythrocytes in obese subjects. These changes in CD47 (show CD47 Antibodies) expression on the erythrocytes surface may be an adaptive response to hyperfibrinogenemia associated with obesity.
Fibrinogen A alpha arginine-glycine-aspartate sequence (residues 95-97) is essential for binding to its erythrocyte receptor (show CD2 Antibodies).
Binding of human fibrinogen to MRP enhances Streptococcus suis survival in host blood in a alphaXbeta2 integrin-dependent manner.
High fibrinogen level is associated with Type-2 diabetes and diabetic vascular disease.
A brief history of some key events in the conversion of fibrinogen to fibrin has been reviewed. (Review)
Preoperative fibrinogen levels appeared as an independent mortality risk factor in non-metastatic colorectal cancer patients with normal GPS (show NBEAL2 Antibodies) scores
We used mass spectrometry of plasma from trauma patients to find that fibrinogen Aalpha-C domain methionine sulfoxide content was selectively-increased in patients with coagulopathy vs. those without coagulopathy. This evidence supports a novel linkage between oxidative stress, coagulopathy, and bleeding after injury
Using a quantum chemical approach method, it has been established that mutations in MMP-10 (show MMP10 Antibodies) and FGA (show FGA Antibodies) proteins led to substantial energetic modifications suggesting an impact on their functions and/or stability in the recurrent pregnancy loss patients.
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.
fibrinogen, A alpha polypeptide