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FOXC2 belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. Additionally we are shipping FOXC2 Antibodies (126) and FOXC2 Kits (26) and many more products for this protein.
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FOXC1 (show FOXC1 Proteins) and FOXC2 are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases
Compound, NC-specific Foxc1 (show FOXC1 Proteins); Foxc2 homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2 (show PITX2 Proteins), and its downstream effector Dkk2 (show DKK2 Proteins), which antagonizes canonical Wnt (show WNT2 Proteins) signaling.
Foxc1 (show FOXC1 Proteins) and Foxc2 maintain glomerular podocyte integrity by regulating the gene expression. Foxc2 plays a more critical role than Foxc1 (show FOXC1 Proteins).
Foxc1 (show FOXC1 Proteins) and Foxc2 have a role in kidney and axial skeleton development.
Our results are consistent with previous reports of Foxc2 expression during early embryogenesis and the Foxc2(CreERT2) mouse provides a tool to investigate spatiotemporal roles of Foxc2 and contributions of Foxc2(+) expressing cells during mouse embryogenesis.
Conditional knockout of Foxc2 gene in kidney has been generated using conditional alleles of single-exon gene by double-selection system.
Data show that segregation of Foxc2 and NFATc1 (show NFATC1 Proteins) transcription factor is closely associated with the highly polarized expression of connexins Cx37 (show GJA4 Proteins), Cx43 (show GJA1 Proteins), and Cx47 (show GJC2 Proteins).
deletion of Foxc1 (show FOXC1 Proteins) and Foxc2 specifically in Pax3 (show PAX3 Proteins)-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb
Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation
Foxc2 enhances proliferation of preadipocytes and inhibits apoptosis of preadipocytes by activating the Akt (show AKT1 Proteins)/mTORC1 and ERK (show EPHB2 Proteins)/mTORC1 signaling pathways
Studied interactions between protein kinase C alpha (PKCalpha (show PKCa Proteins)), FOXC2, and p120-catenin (CTNND1 (show CTNND1 Proteins)) in breast cancer, cell migration/ invasion; found PKCalpha (show PKCa Proteins) acts as an upstream regulator of FOXC2, which in turn represses the expression of p120-catenin (show CTNND1 Proteins), in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer.
FOXC2 and CLIP4 activity correlates to the presence of =7-cm clear cell renal cell carcinomas (ccRCCs) with synchronous metastasis and may be potential molecular predictors of synchronous metastasis of =7-cm ccRCCs.
either a complete loss or a significant gain of FOXC2 function can cause a perturbation of lymphatic vessel formation leading to lymphedema.
Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians.
respectively. Foxc2 is expressed in the developing kidney and therefore congenital renal anomalies may well be associated, potentially as a low penetrance feature. We propose that all individuals diagnosed with Lymphedema distichiasis syndrome should have a baseline renal ultrasound scan at diagnosis
Genomic analysis of blood and excised valve tissue showed down-regulation of FOXC1 (show FOXC1 Proteins) but also FOXC2 expression in the diseased aortic valve. This allows us to speculate on the potential role of FOXC1 (show FOXC1 Proteins) in aortic valve anomalies.
This is the first report of a FOXC2 mutation in hereditary distichiasis in the Chinese population. The findings expand the FOXC2 mutation spectrum and contribute to the understanding of the genotype-phenotype correlation of this disease.
FOXC2 promoted the glycolysis in progression of nasopharyngeal carcinoma by activating YAP (show YAP1 Proteins) signaling
Authors concluded that the lncRNA FOXC2-AS1 (show PTGDR Proteins) may promote doxorubicin resistance in OS by increasing the expression of transcription factor FOXC2, further facilitating ABCB1 (show ABCB1 Proteins) expression.
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in the development of mesenchymal tissues.
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
, forkhead box C2
, forkhead box protein C2
, forkhead box protein C2-like
, brain factor 3
, forkhead homolog 14
, forkhead-related protein FKHL14
, mesenchyme fork head protein 1
, transcription factor FKH-14
, forkhead box C2 (MFH-1 mesenchyme forkhead 1)
, winged helix transcriptional factor MFH-1
, MFH-1,mesenchyme forkhead 1
, forkhead, Drosophila, homolog-like 14