anti-G Protein-Coupled Receptor 183 (GPR183) Antibodies

Human G Protein-Coupled Receptor 183 (GPR183) interaction partners

1. These data suggest a significant role for EBI2 in human CD4(+) T cell migration, notably in patients with multiple sclerosis.

2. Studies provide evidence that EBI2 and oxysterols are important players not only in the immune system but also in the central nervous system. Proper functioning of the EBI2/oxysterol system seems crucial for healthy physiology and prevention of the onset or progression of several neurodegenerative diseases. [review]

3. Human EBI2 (GPR183) expression in mice leads to an abnormally expanded CD5+ B1a B-cell subset and chronic lymphocytic leukemia-like B-cell malignancies.

4. On ligand engagement, EBI2 typically signals via inhibitory G-protein subunit alpha to induce intracellular calcium mobilization, mitogen-activated protein kinase (MAPK) activation, and cell proliferation.

5. this study concludes that EBI2 expression is directly influenced by EBV infection and that BRRF1 is necessary and sufficient for EBI2 upregulation during infection.

6. These results demonstrate a role for EBI2 in astrocyte function and suggest that modulation of this receptor may be beneficial in neuroinflammatory disorders.

7. EBI2 is expressed in primary human monocytes and macrophages.

8. Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression.

9. This model of ligand docking yields important structural insight into the molecular mechanisms mediating EBI2 function.

10. Data indicate that EBI2 expression modulates CXCL13 binding affinity to CXCR5.

11. Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183).

12. REVIEW: functional properties and in vivo biology

13. Based on the constitutive signaling and cellular expression pattern of EBI2, it is suggested that it may function in conjunction with BILF1 in the reprogramming of the cell during EBV infection

14. Structural motifs of importance for the constitutive activity of EBI2: analysis of receptor activation in the absence of an agonist.

Mouse (Murine) G Protein-Coupled Receptor 183 (GPR183) interaction partners

1. This study support the hypothesis that EBI2/oxysterol signalling not only controls immune cell function, but may also adjust how astrocytes sense and respond to inflammatory stimuli

2. GPR183 promotes lymphoid organ development and indicate that oxysterol-GPR183-dependent positioning within tissues controls group 3 innate lymphoid cells activity and intestinal homeostasis

3. These results, for the first time, display a role for EBI2 in myelin development and protection from demyelination under pathophysiological conditions

4. the data indicates that molecules in the EBI2 signalling pathway are sensitive to pro-inflammatory signals, and that EBI2 plays a role in communication between astrocytes and macrophages.

5. EBI2 expressing cells are abundant within multiple sclerosis (MS) white matter lesions.

6. These data identify a role for EBI2 in promoting efficient thymic central tolerance.

7. mice lacking EBI2 in T cells or CD25 in dendritic cells have reduced T follicular helper cells and mount defective T-cell-dependent plasma cell and germinal centre responses

8. findings establish an essential role for EBI2 in CD4(+) DC positioning and homeostasis and in facilitating capture and presentation of blood-borne particulate antigens

9. EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells.

10. Regulated expression of EBI2 on DC populations is therefore critical for the generation and correct positioning of splenic DCs and the initiation of immune responses.

11. Regulation of B cell migration by EBI2 has an important role in controlling the positioning of activated B cells within lymphoid follicles in the early phases of B cell responses during cell differentiation and affinity maturation.

12. These findings establish a role for EBI2 in helping control B cell position at multiple stages during the Ab response

13. ligand targeting EBI2. In turn, this molecule provides a useful tool for further characterization of EBI2 as well as serving as a potent lead compound.

14. important role for EBI2 in promoting B cell localization in the outer follicle, and show that differential expression of this receptor helps position B cells appropriately for mounting T-dependent antibody responses

15. EBI2 provides a previously uncharacterized dimension to B cell migration that is crucial for coordinating rapid versus long-term antibody responses.

Zebrafish G Protein-Coupled Receptor 183 (GPR183) interaction partners

1. Inhibition of Gpr183 significantly upregulates Notch signaling and abolishes embryonic hematopoietic stem and progenitor cells emergence.