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GAB3 is a member of the GRB2-associated binding protein gene family.
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we conclude that Gab3 overexpression in human glioma mediates Akt (show AKT1 Proteins) activation and cancer cell proliferation
Together, our results suggest that Gab3 expression in CRC (show CALR Proteins) cells is important for Akt (show AKT1 Proteins)-Erk (show EPHB2 Proteins) activation and cell proliferation.
The carboxy-terminal SH3 domain of the adapter prot (show GRAP2 Proteins)ein Mona interacts with the atypical proline-rich domain of Gab3 to mediate late signaling of the macrophage colony-stimulating factor receptor.
Hematopoiesis in mice lacking Gab3 is not impaired, macrophages develop in normal numbers and exhibit normal function, and there is no major immune deficiency in T- and B-lymphocyte responses to protein antigens or during viral infection.
Induced expression and association of the Mona/Gads (show GRAP2 Proteins) adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation. (Gab3 scaffolding protein)
Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent
This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Two transcript variants encoding different isoforms have been found for this gene.
GRB2-associated binding protein 3
, GRB2-associated-binding protein 3
, growth factor receptor bound protein 2-associated protein 3
, DOS/Gab family member 3
, GRB2-associated binder 3
, Gab3 scaffolding protein