Granulysin Proteins (GNLY)

The product of GNLY is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. Additionally we are shipping Granulysin Antibodies (59) and Granulysin Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GNLY 10578 P22749
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Top Granulysin Proteins at

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
NSO cells Human Un-conjugated 4 pack Log in to see 10 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
Human Un-conjugated   1 mg Log in to see 6 Days

GNLY Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,

Top referenced Granulysin Proteins

  1. Human GNLY Protein expressed in Wheat germ - ABIN1790513 : Chung, Hung, Yang, Su, Huang, Wei, Chin, Chiou, Chu, Ho, Yang, Lu, Wu, Liao, Chen: Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. in Nature medicine 2008 (PubMed)

More Proteins for Granulysin (GNLY) Interaction Partners

Human Granulysin (GNLY) interaction partners

  1. These studies provide a deeper insight into the subcellular localization and release mechanisms of the individual GNLY species.

  2. Increased seminal granulysin has a negative impact on spermatogenesis in infertile men in general and in infertility associated with varicocele in particular.

  3. The results suggest granulysin as a novel marker for a subset of cytotoxic natural killer cell derived malignancies

  4. These results suggest that the 15 kDa granulysin exhibits a novel mechanism in bacteria killing in a way that's different from most antimicrobial peptides.

  5. Decreased blood granulysin at the protein level, is linked to the immunological condition of latent tuberculosis infection.

  6. Carbamate pesticides significantly reduced the intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN in NK-92CI cells.

  7. serum GNLY is closely associated with the clinical characteristics of nasopharyngeal carcinoma and may be a potential biomarker for nasopharyngeal carcinoma

  8. GNLY delivers Gzms into three protozoan parasites (Trypanosoma cruzi, Toxoplasma gondii and Leishmania major), in which the Gzms generate superoxide and inactivate oxidative defense enzymes to kill the parasite.

  9. Studies indicate that cytotoxic mechanisms mediated by granulysin and TRAIL (TNF-related apoptosis inducing ligand) seem to be less secondary effects on normal tissues.

  10. High Granulysin expression is associated with Cutaneous T Cell Lymphoma and Sezary Syndrome.

  11. A three-way interaction between SNPs in HLA-DQ and GNLY was identified in terms of HBV clearance.

  12. GNLY-expressing lymphocytes, probably attracted by IL-15, not only participate partially in myocardial cell apoptosis, but also hasten resolution of cardiac leukocyte infiltration in patients with myocardial infarction.

  13. Peptides encoded by this gene display antimicrobial activity against S. typhimurium, L. monocytogenes, E. coli, S. aureus, C. neoformans, C. albicans, L. major, and M. tuberculosis.

  14. Serum granulysin levels were significantly elevated in both acute and chronic alopecia areata patients.

  15. Human, but not rodent, cytotoxic granules also contain granulysin, an antimicrobial peptide in addition to granzymes; study shows that granulysin delivers granzymes into bacteria to kill diverse bacterial strains.

  16. It was concluded taht granulysin induces apoptosis on hematological tumor cells and on cells from B-cell lymphocytic leukemia patients, opening the door to research on its use as a new anti-tumoral treatment.

  17. suggested that the alteration of circulating granulysin has potential function in host immune response against TB and HIV/TB coinfection

  18. study to determine: expression of GNLY at the gene and protein levels at the maternal-fetal interface, relationship(s) between GNLY and perforin, and GNLY secretion by stimulated NK cells

  19. Granulysin is closely associated with the characteristics of NK-cell neoplasms and serum granulysin may serve as a novel biomarker for these disorders.

  20. GNLY polymorphism genotypes and diplotypes were associated with the chronicity of HBV

Cow (Bovine) Granulysin (GNLY) interaction partners

  1. Intercaruncular epithelium granulysin may play important roles in the establishment and maintenance of gestation during normal pregnancy.

Granulysin (GNLY) Protein Profile

Protein Summary

The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Granulysin Proteins (GNLY)

  • granulysin (GNLY)
  • 519 protein
  • D2S69E protein
  • LAG-2 protein
  • LAG2 protein
  • NKG5 protein
  • TLA519 protein

Protein level used designations for Granulysin Proteins (GNLY)

granulysin , T-cell activation protein 519 , T-lymphocyte activation gene 519 , lymphocyte-activation gene 2 , lymphokine LAG-2

459370 Pan troglodytes
100125622 Ovis aries
10578 Homo sapiens
404173 Bos taurus
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