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heat shock protein that binds alpha-filamin [RGD, Feb 2006].. Additionally we are shipping HSPB7 Antibodies (63) and HSPB7 Kits (9) and many more products for this protein.
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Loss of Hspb7 in zebrafish or human cardiomyocytes stimulated autophagic pathways and expression of the sister gene encoding Hspb5. Inhibiting autophagy caused FilaminC aggregation in HSPB7 mutant human cardiomyocytes and developmental cardiomyopathy in hspb7 mutant zebrafish embryos.
our findings characterize HSPB7 as an intercalated disc protein and suggest it has an essential role in maintaining intercalated disc integrity and conduction function in the adult heart.
Patients with central sleep apnea and congestive heart failure had higher T allele frequencies in the HSPB7 gene.
HSPB7 loci is associated in the pathophysiologuy of ischemic heart failure.
Results imply that HSBP7 is likely to be a tumor suppressor gene regulated by p53 and its downregulation by hypermethylation may play a critical role in renal carcinogenesis.
HSPB7 is a potential early biomarker after MI and serves as an independent risk factor of ACS in patients with acute chest pain.
Overexpression of HSPB1, as well as HSPB6, HSPB7 and HSPB8 independently protect against tachycardia remodeling by attenuation of the RhoA GTPase pathway at different levels.
Data show a significant association between a SNP in HSPB7 gene (rs1739843, minor allele frequency 39%) and idiopathic DCM.
The rs1738943 shows that although this SNP is located within HSPB7, it resides in a block of high LD that spans HSPB7 and a nearby gene, CLCNKA, which encodes a voltage-sensitive chloride channel expressed mainly in the kidney.
Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease.
HSPB7 constitutively localized to SC35 splicing speckles, driven by its N-terminus. Unlike HSPB1 and HSPB5, that chaperoned heat unfolded substrates and kept them folding competent, HSPB7 did not support refolding.
The authors found that deleting HSPB7 resulted in uncontrolled elongation of actin filaments and the formation of atypical actin filament bundles in cardiomyocytes.
these data indicate that MEF2 and AP-1 confer antagonistic regulation of Hspb7 gene expression in skeletal muscle, with implications for autophagy and muscle atrophy.
this paper shows that skeletal-muscle-specific ablation of the HspB7 causes postnatal death owing to a respiration defect, with progressive myopathy phenotypes in the diaphragm
These results imply that HspB2 and HspB7 might be up-regulated by ethanol during the short-term differentiation of neural stem cells.
heat shock protein that binds alpha-filamin
cardiovascular heat shock protein
, heat shock 27kDa protein family, member 7 (cardiovascular)
, heat shock 27kD protein family, member 7 (cardiovascular)
, heat shock protein beta-7
, heat shock protein 25 kDa 2 (cardiovascular)
, protein p19/6.8
, heat shock 27kD protein family member 7