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The enzyme encoded by HAGH is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Additionally we are shipping Hydroxyacylglutathione Hydrolase Antibodies (73) and Hydroxyacylglutathione Hydrolase Proteins (17) and many more products for this protein.
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Glyoxalase expression prevents against ischemic neuronal cell damage and ameliorates ischemic injury.
Down regulation of Glyoxalase II was observed in cases of diabetic retinopathy as compared to controls.
The critical role of glyoxalases as regulators of tumorigenesis in the prostate through modulation of various critical signaling pathways, and an overview of the current knowledge on glyoxalases in bladder, kidney and testis cancers is reviewed. (GLO1, GLO2)
epidermal expression stronger in older skin donors
Glo2, together with Glo1, represents a novel mechanism in prostate cancer progression as part of a pathway driven by PTEN/PI3K/AKT/mTOR signaling.
This article reports for the first time a possible additional role of Glo2 that, after interacting with a target protein, is able to promote S-glutathionylation.
Studies indicate that the most extensively investigated The most extensively investigated glyoxalase enzymes are glyoxalase I and glyoxalase II (Glo1 and Glo2).
This study suggested that HAGH, rs11859266 and rs3743852 showed significant associations with schizophrenia in males at allelic and genotype levels.
No association between genetic variants of the HAGH gene and autism spectrum disorder was found.
hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II
Overexpression of glyoxalase II is associated with kidney tumor
Data show that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73.
In androgen-dependent prostate cancer cells, testosterone upregulates GLO2 mRNA levels. In androgen-independent prostate cancer cells, it downregulates GLO2 mRNA.
Human glyoxalase II contains an Fe(II)Zn(II) center but is active as a mononuclear Zn(II) enzyme
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Two transcript variants encoding different isoforms have been found for this gene.
, glyoxylase II
, glx II
, glyoxalase II
, glyoxylase 2
, hydroxyacylglutathione hydrolase, mitochondrial
, round spermatid protein RSP29
, hydroxyacylglutathione hydroxylase
, Germ cell-specific protein
, Glx II
, Glyoxalase II