anti-Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) Antibodies

ID4 encodes a member of the inhibitor of DNA binding (ID) protein family. Additionally we are shipping ID4 Proteins (6) and ID4 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ID4 15904 P41139
ID4 291023  
ID4 3400 P47928
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Top anti-ID4 Antibodies at antibodies-online.com

Showing 10 out of 86 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ID4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  293T cell lysate ID4 is strongly supported by BioGPS gene expression data to be expressed in Human HEK293T cells Lanes :  Lane 1: 10ug MDA-MB231 lysateLane 2: 10ug MCF7 lysate   Primary Antibody Dilution :   1:1000    Secondary Antibody :  Anti-rabbit-HRP   Secondary Antibody Dilution :   1:10,000   Gene Name :  ID4   Submitted by :  Maria Teresita Branham. Facultad de Cs Médicas-UNCuyo 100 μL Log in to see 2 to 3 Days
$319.00
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-ID4 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  HepG2 cell lysate Host:  Rabbit  Target Name:  ID4  Sample Type:  HepG2  Lane A:  Primary Antibody  Lane B:  Primary Antibody + Blocking Peptide  Primary Antibody Concentration:  2.5ug/mL  Peptide Concentration:  2.0ug/mL  Lysate Quantity:  25ug/lane  Gel Concentration:  12% 100 μL Log in to see 2 to 3 Days
$249.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of ID4 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with t Western blot analysis of ID4 expression in HEK293T (A), HepG2 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2 cells, using ID4 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Dog Rabbit Un-conjugated WB 100 μg Log in to see 11 to 14 Days
$493.17
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ID4 Antibody (N-term) (ABIN653935) in mouse bladder tissue lysates (35 µg/lane). ID4 (arrow) was detected using the purified polyclonal antibody. ID4 Antibody (N-term) (ABIN653935) IHC analysis in formalin fixed and paraffin embedded bladder followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p), WB Flow cytometric analysis of 293 cells using ID4 Antibody (N-term) Cat.-No AP52145PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin fixed and paraffin embedded bladder carcinoma reated with ID4 Antibody (N-term) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 11 to 14 Days
$484.00
Details

Top referenced anti-ID4 Antibodies

  1. Human Polyclonal ID4 Primary Antibody for WB - ABIN516801 : Oatley, Kaucher, Racicot, Oatley: Inhibitor of DNA binding 4 is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells in mice. in Biology of reproduction 2011 (PubMed)

  2. Dog (Canine) Polyclonal ID4 Primary Antibody for WB - ABIN2780374 : Yu, Liu, Vandeusen, Becknell, Dai, Wu, Raval, Liu, Ding, Mao, Liu, Smith, Lee, Rassenti, Marcucci, Byrd, Caligiuri, Plass: Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. in Nature genetics 2005 (PubMed)
    Show all 2 Pubmed References

More Antibodies against ID4 Interaction Partners

Mouse (Murine) Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) interaction partners

  1. ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states

  2. results indicate that Id4 marks spermatogonial stem cells in the mouse testis.

  3. ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.

  4. Id4 regulates NKX3.1, Sox9 and PTEN.

  5. Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary

  6. High expression levels of Id1-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.

  7. CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell

  8. ID4 promotes mammary gland development by suppressing p38MAPK activity.

  9. Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.

  10. Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.

  11. ID4 has a role in adipocyte differentiation and the implications of this regulation for adipose tissue formation

  12. ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.

  13. Id4 has a unique and complex function in regulating neural stem cell proliferation and differentiation

  14. Id4 has a critical role in regulating neural precursor cell proliferation and differentiation

  15. ID proteins (ID1, ID2, ID3 and ID4) were significantly increased in Mecp2-deficient Rett syndrome brain; ID genes are ideal targets for MeCP2 regulation of neuronal maturation that may explain the molecular pathogenesis of Rett syndrome

  16. these data support the role of Id4 as oligodendrocyte differentiation inhibitor

Zebrafish Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) interaction partners

  1. id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt signaling in the developing AVC endocardium

Human Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) interaction partners

  1. Low ID4 expression is associated with breast cancer.

  2. These findings indicate that ID4 acts as a tumour suppressor in myeloid malignancies, and ID4 methylation is a potential biomarker in predicting disease progression and treatment outcome.

  3. results highlight a key role for MALAT1 in control of VEGFA isoforms expression in breast cancer cells expressing gain-of-function mutant p53 and ID4 proteins.

  4. Study demonstrates that ID4, can promote p53- dependent apoptosis and senescence in prostate cancer cells by specifically modifying the acetylation of p53, which increases its transcriptional activity and promotes the expression of pro-apoptotic and cell cycle regulatory genes.

  5. The cellular uptake of inhibitor of DNA binding 4 protein (ID4) resulted in increased apoptosis, decreased proliferation and colony formation.

  6. Several lines of evidence suggest ID4 may suppress BRCA1 function in basal-like breast cancer (BLBC) and in doing so, define a subset of BLBC patients who may respond to therapies traditionally used in BRCA1-mutant cancers. This review highlights recent advances in our understanding of the requirement for ID4 in mammary lineage commitment and the role for ID4 in BLBC.

  7. The expression of Id4 protein was up-regulated in tumor tissues from hepatocellular carcinoma (HCC) patients, and overexpression of Id4 promoted HCC cell proliferation, clonogenicity in vitro, and tumorigenicity in vivo.

  8. ID4 selectively regulates AR activity through direct interaction with FKBP52.

  9. High ID4 expression is associated with basal breast cancer.

  10. A cell-autonomous positive-signaling circuit is associated with the PDGFB-NO-ID4-regulatory axis in glioblastoma cells.

  11. ID4 expression induces AR expression in PC3 cells, which generally lack AR. ID4 expression increased apoptosis and decreased cell proliferation and invasion.

  12. CEACAM1 is able to maintain the active transcription of ID4 by an epigenetic mechanism involving HDAC4 and CaMK2D, and the same kinase enables lumen formation by CEACAM1

  13. In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2)early growth response (EGR)2 and NR4A2EGR3. Therefore, RUNX1, NR4A2, EGR2, EGR3 and ID4 may be key genes associated with the pathogenesis of DS.

  14. changes in gene amplification in the mitochondrial genome and in the ID4 gene promoter methylation region in patients with chronic aplastic anemia (CAA) suffering from Kidney (Shen) yin deficiency or Kidney yang deficiency, were analyzed.

  15. Hypermethylation of ID4 promotes the proliferation of Burkitt's lymphoma cells; ID4 may function as a tumor suppressor and can be targeted with demethylating compounds such as CdR for the treatment of Burkitt's lymphoma

  16. the unmethylation of ID4 is an epigenetic predictor of BRCAness phenotype in breast tumors.

  17. ID4 hypomethylation is present in tamoxifen-resistant breast cancer, and it may serve as a potential biomarker in distinguishing tamoxifen-resistant breast cancer.

  18. ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 is specifically expressed by a subset of human basal-like breast cancer that possess a very poor prognosis and a transcriptional signature similar to a mammary stem cell.

  19. The results showed that the detection of ID4 methylation positivity rates and levels could be a useful biomarker for MDS diagnosis.

  20. The chromosomal deletion 6p22.3 could result in the aberrant activation and mis-expression of ID4 in the limb bud, thereby causing mesomelic dysplasia Savarirayan type.

ID4 Antigen Profile

Protein Summary

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.

Gene names and symbols associated with ID4

  • inhibitor of DNA binding 4 (Id4) antibody
  • inhibitor of DNA binding 4, HLH protein (Id4) antibody
  • inhibitor of DNA binding 4 (id4) antibody
  • inhibitor of DNA binding 4, HLH protein S homeolog (id4.S) antibody
  • inhibitor of DNA binding 4, HLH protein (ID4) antibody
  • bhlhb27 antibody
  • cb547 antibody
  • fb77d04 antibody
  • id4 antibody
  • id4a antibody
  • IDB4 antibody
  • sb:cb547 antibody
  • wu:fb77d04 antibody
  • zgc:123214 antibody

Protein level used designations for ID4

DNA-binding protein inhibitor ID-4 , inhibitor of DNA binding 4 a , class B basic helix-loop-helix protein 27

GENE ID SPECIES
15904 Mus musculus
291023 Rattus norvegicus
664761 Danio rerio
380396 Xenopus laevis
374150 Gallus gallus
3400 Homo sapiens
610666 Canis lupus familiaris
100144508 Sus scrofa
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