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anti-Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Antibodies

ICMT encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. Additionally we are shipping Isoprenylcysteine Carboxyl Methyltransferase Proteins (6) and Isoprenylcysteine Carboxyl Methyltransferase Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ICMT 23463 O60725
ICMT 57295 Q9EQK7
ICMT 170818  
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Top anti-Isoprenylcysteine Carboxyl Methyltransferase Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ICMT Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human heart 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
$484.00
Details
Chicken Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB Antibody is used in Western blot to detect ICMT in T47D (left) and SK-BR-3 (right) tissue lysate 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of extract of various cells, using ICMT antibody. Western blot analysis of extracts of various cell lines, using ICMT antibody (ABIN4903998) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated WB ICMT antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (33.7 KDa) . 50 μL 11 to 12 Days
$305.71
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit APC ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details

Top referenced anti-Isoprenylcysteine Carboxyl Methyltransferase Antibodies

  1. Human Polyclonal ICMT Primary Antibody for ELISA, WB - ABIN543475 : Van Dessel, De Busser, Lagrou: Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells. in The international journal of biochemistry & cell biology 2002 (PubMed)
    Show all 3 Pubmed References

  2. Cow (Bovine) Polyclonal ICMT Primary Antibody for WB - ABIN2773889 : Nuthalapaty, Lu, Ramin, Nuthalapaty, Ramin, Ramsey: Is there a preferred gestational age threshold of viability?: a survey of maternal-fetal medicine providers. in The journal of maternal-fetal & neonatal medicine 2007 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Isoprenylcysteine Carboxyl Methyltransferase Interaction Partners

Human Isoprenylcysteine Carboxyl Methyltransferase (ICMT) interaction partners

  1. ICMT expression is repressed by WT p53. This work unveils a link between postprenylation protein processing and the p53 pathway, indicating that the functional interplay between WT and mutant p53 alters ICMT levels, thereby affecting tumor aggressiveness.

  2. Using cell culturing system, mouse model and patient samples, this work is the first to demonstrate the essential roles of Icmt in ovarian cancer via Ras signaling, particularly on its response to chemotherapy.

  3. Apoptosis, but not autophagy, that is induced via p21-activated BNIP3 expression accounts for the efficacy of ICMT inhibition in sensitive pancreatic cancer cells in both in vitro and in vivo models. In contrast, cells resistant to ICMT inhibition demonstrated no mitochondria dysfunction or p21 signaling changes under ICMT suppression

  4. ICMT catalyzed carboxylmethylation is critical for RAB4A activation and interaction with effectors, its localization to endosomes and recycling vesicles, and hence important for RAB4A-dependent integrin beta3 recycling to plasma membrane.

  5. ICMT function is critical for the tumorigenesis capacity of naturally occurring mutant KRAS human cancer cells.

  6. simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML.

  7. impact of Icmt on tumorigenic processes

  8. Silencing ICMT in osteosarcoma cells decreased Notch1 signaling in response to stimulation with cell-surface ligands.

  9. a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.

  10. modulation of pcCMT activity in retinoic acid (RA)-treated SH-SY5Y neuroblastoma cells

  11. ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway and appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1 in endothelial cells.

  12. findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase methylation and activation and its downstream antiapoptotic signaling pathway.

  13. These studies identify isoprenylcysteine carboxyl methyltransferase as a potential target for reducing the growth of K-Ras- and B-Raf-induced malignancies.

  14. ICMT inhibition induces endothelial cell apoptosis through GRP94

  15. Icmt traverses the Eendoplasmic reticulum membrane eight times, with both N and C termini disposed toward the cytosol and with a helix-turn-helix structure comprising transmembrane (TM) segments 7 and 8.

  16. Inhibition of isoprenylcysteine carboxylmethyltransferase (Icmt) decreases activation of RhoA and Rac1, and in the absence of Icmt activity, addition of exogenous RhoA or Rac1 partially rescues directed and random migration, respectively.

Mouse (Murine) Isoprenylcysteine Carboxyl Methyltransferase (ICMT) interaction partners

  1. Using cell culturing system, mouse model and patient samples, this work is the first to demonstrate the essential roles of Icmt in ovarian cancer via Ras signaling, particularly on its response to chemotherapy.

  2. simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML.

  3. ICMT deficiency precisely phenocopied Notch1 deficiency in the Pdx1-Cre;LSL-KrasG12D model by exacerbating pancreatic intraepithelial neoplasias, promoting facial papillomas, and derepressing Wnt signaling.

  4. findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase methylation and activation and its downstream antiapoptotic signaling pathway.

  5. inactivating Icmt reduced splenomegaly, the number of immature myeloid cells in peripheral blood, tissue infiltration by myeloid cells, reduced lung tumor development and myeloproliferation phenotypes in a mouse model of K-RAS-induced cancer.

Cow (Bovine) Isoprenylcysteine Carboxyl Methyltransferase (ICMT) interaction partners

  1. ICMT inhibition induces endothelial cell apoptosis through GRP94

Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Antigen Profile

Protein Summary

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Gene names and symbols associated with ICMT

  • isoprenylcysteine carboxyl methyltransferase (ICMT) antibody
  • isoprenylcysteine carboxyl methyltransferase (Icmt) antibody
  • isoprenylcysteine carboxyl methyltransferase (icmt) antibody
  • isoprenylcysteine carboxyl methyltransferase (Bcen_5417) antibody
  • isoprenylcysteine carboxyl methyltransferase (Acid_0983) antibody
  • isoprenylcysteine carboxyl methyltransferase (Bcenmc03_4825) antibody
  • cobalt-zinc-cadmium resistance protein (RPIC_RS08670) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Mesil_1887) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Slip_1333) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Deba_2487) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Bresu_2161) antibody
  • isoprenylcysteine carboxylmethyltransferase family protein (MPET_RS04760) antibody
  • isoprenylcysteine carboxylmethyltransferase family protein (MPET_RS08305) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Saut_0066) antibody
  • isoprenylcysteine carboxyl methyltransferase (Intca_3523) antibody
  • isoprenylcysteine carboxyl methyltransferase (Deima_2891) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Despr_1203) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Deipr_0831) antibody
  • Isoprenylcysteine carboxyl methyltransferase (Theth_0229) antibody
  • isoprenylcysteine carboxyl methyltransferase S homeolog (icmt.S) antibody
  • 1700008E11Rik antibody
  • C80758 antibody
  • fcmt antibody
  • Gm13095 antibody
  • HSTE14 antibody
  • im:6895697 antibody
  • MST098 antibody
  • MSTP098 antibody
  • OTTMUSG00000010406 antibody
  • pcCMT antibody
  • PCMT antibody
  • PPMT antibody
  • STE14 antibody
  • zgc:110258 antibody

Protein level used designations for ICMT

prenylated protein carboxyl methyltransferase , prenylcysteine carboxyl methyltransferase , protein-S isoprenylcysteine O-methyltransferase , protein-S-isoprenylcysteine O-methyltransferase , PPMT , farnesyl cysteine carboxyl methyltransferase , pcCMT , prenylcysteine carboxyl methlytransferase , isoprenylcysteine carboxyl methyltransferase , Isoprenylcysteine carboxyl methyltransferase , FCMT

GENE ID SPECIES
23463 Homo sapiens
57295 Mus musculus
170818 Rattus norvegicus
419373 Gallus gallus
550281 Danio rerio
4094605 Burkholderia cenocepacia AU 1054
4430863 Candidatus Solibacter usitatus Ellin6076
6127637 Burkholderia cenocepacia MC0-3
6287318 Ralstonia pickettii 12J
9251399 Meiothermus silvanus DSM 9946
9274122 Syntrophothermus lipocalidus DSM 12680
9494959 Desulfarculus baarsii DSM 2075
9504035 Brevundimonas subvibrioides ATCC 15264
9743393 Methanoplanus petrolearius DSM 11571
9744111 Methanoplanus petrolearius DSM 11571
9757577 Sulfurimonas autotrophica DSM 16294
10086362 Intrasporangium calvum DSM 43043
10152256 Deinococcus maricopensis DSM 21211
10173921 Desulfobulbus propionicus DSM 2032
10256310 Deinococcus proteolyticus MRP
10884973 Thermotoga thermarum DSM 5069
397717 Xenopus laevis
489628 Canis lupus familiaris
100514410 Sus scrofa
785548 Bos taurus
100725749 Cavia porcellus
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