Laminin, alpha 2 Proteins (LAMA2)

Laminin, an extracellular protein, is a major component of the basement membrane. Additionally we are shipping Laminin Antibodies (54) and Laminin Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LAMA2 3908 P24043
LAMA2 16773  
Rat LAMA2 LAMA2 309368  
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Top Laminin Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days

LAMA2 Proteins by Origin and Source

Origin Expressed in Conjugate

Mouse (Murine)

More Proteins for Laminin, alpha 2 (LAMA2) Interaction Partners

Zebrafish Laminin, alpha 2 (LAMA2) interaction partners

  1. analysis of the caf zebrafish model of MDC1A, which has a mutation in LAMA2

  2. The degenerative muscle phenotype in the zebrafish dystrophic mutant, candyfloss (caf) results from mutations in the laminin alpha2 (lama2) gene.

Human Laminin, alpha 2 (LAMA2) interaction partners

  1. Using high-throughput technology identify LAMA-2 as a candidate medullary sponge kidney disease biomarker possibly employable in future for the early diagnosis of this disease.

  2. Differential protein expression of collagen IV (show COL4 Proteins), laminin alpha2, and nidogen-1 (show NID1 Proteins) indicated basal lamina remodeling develops in ischemic failing versus nonfailing human hearts.

  3. Next generation sequencing was found to be useful for molecular diagnosis of a confirmed case of merosin deficient congenital muscular dystrophy.

  4. did not find positive association signals of the four single nucleotide polymorphisms in the LAMA2 and EGR1 (show EGR1 Proteins) genes with high myopia

  5. By analyzing the gene test we found that compound heterozygous LAMA2 mutation inherited from the parents. One coming from the father was a gross deletion expanding from exon 36 to exon 65. The from the mother was a missense mutation c.1358G>C

  6. This report widens the clinical spectrum of cerebral manifestations related with mutations in LAMA2

  7. Data showed miR (show MLXIP Proteins)-29a/c as novel regulators of LAMA2 in ependymoma based on miRNA-mRNA covariation and sequence-based target predictions.

  8. This study demonstrates a wide clinical spectrum of LAMA2-related muscular dystrophy and its prevalence in an LGMD2 (show CAPN3 Proteins) cohort, which indicates that LAMA2 muscular dystrophy should be included in the LGMD2 (show CAPN3 Proteins) nomenclature.

  9. Crystal structure of LAMM L4 domain

  10. Data find high frequency mutations in LAMA2 protein in hepatocellular carcinoma (HCC (show FAM126A Proteins)) patients. Its lower expression levels correlate with tumor progression, poor survival and higher chance of cancer recurrence.

Mouse (Murine) Laminin, alpha 2 (LAMA2) interaction partners

  1. Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (show NRG1 Proteins) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.

  2. results indicate a novel role for laminin-dystroglycan interactions in the cooperative integration of astrocytes, endothelial cells, and pericytes in regulating the Blood Brain Barrier.

  3. Laminin alpha2-mediated FAK (show PTK2 Proteins) activation in podocytes is an important early event in Alport glomerular pathogenesis.

  4. The effects of merosin knockout on alkaline phosphatase activity in the liver of normal and dystrophic mice is reported.

  5. The data of this study suggested that prosurvival Lama (show LAMA1 Proteins) interactions in the developing postnatal VZ-SVZ germinal zone regulate the ability, or timing, of oligodendrocyte production to occur appropriately.

  6. Levels of both lipid rafts and raft-located acetylcholinesterase (show AChE Proteins) dimers increase in muscle of mice with muscular dystrophy by merosin deficiency.

  7. Overexpression of laminin alpha1 chain that lacks the dystroglycan binding LG4-5 domains in alpha2 chain deficient mice resulted in prolonged lifespan and improved health.

  8. Ku70 (show XRCC6 Proteins) is a regulator of Bax (show BAX Proteins)-mediated pathogenesis in laminin-alpha2-deficiency muscle cells.

  9. this study identified a novel spontaneous mouse model of human congenital muscular dystrophy with laminin alpha2 chain deficiency, named dy(Pas (show PASK Proteins))/dy(Pas (show PASK Proteins)). Homozygous animals rapidly developed a progressive muscular dystrophy leading to premature death.

  10. merosin contributes to muscle passive stiffness, viscoelasticity, and contractility

Laminin (LAMA2) Protein Profile

Protein Summary

Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.

Gene names and symbols associated with Laminin, alpha 2 Proteins (LAMA2)

  • laminin subunit alpha 2 (LAMA2)
  • laminin, alpha 2 (LAMA2)
  • laminin, alpha 2 (lama2)
  • laminin subunit alpha-2 (LOC100460380)
  • laminin subunit alpha-2 (LOC100545053)
  • laminin subunit alpha 2 (lama2)
  • laminin, alpha 2 (Lama2)
  • laminin subunit alpha 2 (Lama2)
  • 5830440B04 protein
  • dy protein
  • LAMA2 protein
  • LAMM protein
  • mer protein
  • merosin protein
  • mKIAA4087 protein

Protein level used designations for Laminin, alpha 2 Proteins (LAMA2)

laminin alpha 2 subunit , laminin, alpha 2 (merosin, congenital muscular dystrophy) , laminin, alpha 2 , caf , candyfloss , laminin alpha 2 chain , unm teg15a , unm tk209 , laminin subunit alpha-2-like , laminin M chain , laminin subunit alpha-2 , laminin-12 subunit alpha , laminin-2 subunit alpha , laminin-4 subunit alpha , merosin heavy chain , dystrophia muscularis

472122 Pan troglodytes
484121 Canis lupus familiaris
100049705 Danio rerio
100405831 Callithrix jacchus
100460380 Pongo abelii
100484712 Ailuropoda melanoleuca
100545053 Meleagris gallopavo
100565785 Anolis carolinensis
100583654 Nomascus leucogenys
3908 Homo sapiens
100350500 Oryctolagus cuniculus
16773 Mus musculus
309368 Rattus norvegicus
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